First Aid 327-332 Endo Flashcards
Which thyroid disorder is associated with Inc CK?
Hypothyroidism - myopathy (Normal Ck in Hyper)
Which thyroid disorder is associated with thinning, fine hair?
hyperthyroidism
Thyroid disorder with inc #/sensitivity of B adr receptors?
Hyperthyroid
Causes of smooth/diffuse goiter?
Graves, Hashimoto, Iodine def, TSH secreting pit adenoma
Causes of nodular goiter?
Toxic multinodular goiter, Thyroid adenoma, Thyroid cancer, Thyroid cyst
HLA # associated with Hashimoto’s?
HLA-DR5
Which thyroid disorder is assoc w/ non Hodgkin Lymphoma?
Hashimoto
Most common cause of thyroid disgenesis?
Congential hypothyroid (Cretinism)
Neck and jaw pain is assoc with which thyroid disorder?
Subacute granulomatous thyroiditis - jaw pain, very tender thyroid
Which disease is assoc with a rock like painless goiter? Why rock-like? (patho)
Riedel thyroiditis - thyroid replaced with fibrous tissue w/ inflammatory infiltrate.
What is the Wolff Chaikoff effect?
Thyroid gland will downregulate in response to inc iodide
What type of HS and what type of Ig is involved in Graves?
HS-II, IgG
The release of cytokines in the retroorbital space leads to secretion of _____ by _____ cells? (Eventually resulting in exophthalmus in Graves)
Inc secretion of hydrophilic GAGs by fibroblasts
focal patches of hyperfunctioning follicular cells = which thyroid disease?
Toxic multinodular goiter
Tall follicular epithelial cells with scalloped colloid is seen in which thyroid disease?
Graves
Tx for Thyoid Storm?
BB, Propylthiouracil, Corticosteroids, Potassium Iodide
Jod-Basedow phenomenon
If a patient that is previously iodine deficient and has partially autonomous thryroid tissue, is then made iodine replete —> thyrotoxicosis
Most common histology of thyroid adenoma?
follicular - with no capsular or vascular invasion
Why is thyroid cancer treatment associated with hypocalcemia?
Due to surgery leading to possible removal of parathyroid glands
Which two Thyroid cancers are associated with Ret mutation?
Papillary CA and MEN 2B
Empty appearing nuclei with a central clearing and nuclear grooves - which Thyroid disease?
Papillary (Orphan Annie eyes)
Which thyroid cancer stains with Congo Red?
Medullary CA - sheets of cells in amyloid stroma
High PTH and low Ca is which Parathyroid disordeR?
2ndary Hyper PTH - vitamin D def, chronic renal failure
Low Ca and Low PTH?
Primary HypoPTH
High Ca and low PTH?
PTH indep hyper Calcemia - excess intake of Ca, cancer
Which endocrine disorder is associated with carpal spasm when one takes blood pressure?
HypoPTH - Trousseau sign
Which endocrine disorder is assoc with shortened 4th/5th digits, and short stature?
Pseudohypoparathyroidism type 1A
Which parathyroid disease is associated with a defective Gs protein alpha subunit ?
Psuedohypoparathyroidism type 1A and Pseudopseudohypoparathyroidism
Which parathyroid disorder is associated with maternal imprinting? paternal imprinting?
Pseudohypoparathyroidism 1A - mother
Pseudopseudohypoparathyroidism - father
Which endocrine disorder is associated with a defective Ca 2+ sensing receptor?
Familial hypocalciuric hypercalcemia
Which endocrine disorder is assoc with constipation, and flank pain?
Primary hyperparathyroidism
Inc cAMP in urine is seen with which endocrine disordeR?
Primary Hyperparathyroidism
The cystic bone lesions are filled with brown tissue made of what?
Osteoclasts and deposited hemosiderin from hemorrhages
Most common manifestations of a pituitary adenoma?
Prolactinoma - galactorrhea, amenorrhea
Hyperpigmentation, headaches, and bitemporal hemianopsia is associated with which endocrine disorder?
Nelson syndrome
