Exam 3 Study Guide Flashcards
List the functions of the skeletal system.
Support Protection Movement Storage Hematopoiesis
Support
Provide a framework for the body.
Protection
Protects internal organs.
Movement
Skeletal muscles attach to bones to move body parts.
Storage
Calcium(98%), Fat (Triglycerides)
Hematopoiesis
production of blood cells (RBCs and WBCs) by hematopoietic stem cells (hematocytoblasts)
How are bones classified
Long bones (Humerus) Short bones (Carpal bones) Flat bones (Sternum) Irregular bones (Vertebra)
What is bone matrix comprised of?
67% Hydroxyapaties
-Calcium Phosphate
-Calcium Carbonate
33% Collagen
Name the 4 bone cells
Osteogenic
Osteoblast
Osteoclast
Osteocytes
Osteogenic cells
Mitotically active
Stem cells
Osteoblast
Bone forming cells
Secrete bone matrix
Collagen and Osteoid
Osteoclast
Giant multinucleate cell derived from stem cells in bone matrix
Degrade bone matrix
Ruffled border
Increase surface area for degrading bone matrix
Osteocytes
Reside in lacuna
Monitor their environment
Maintain bone matrix by regulating osteoblasts and osteoclasts
Compact Bone
Outer parts of bone, strengthens it
Spongy Bone
Inner parts of bones
Allows for nerve and vessels to run through the bone
Diaphysis
Shaft
Epiphysis
Ends of bone
Epiphyseal line
Former growth plate
Articular Cartilage
Cartilage at ends of bone
- Made of hyaline
- No nerves
- Enables bones to glide
Yellow Bone Marrow
Fat Storage
Red Bone Marrow
Production of red blood cells
Contains hematopoietic stem cells
Stem cells can differentiate into…
WBC
RBC
Platelets
Parts of Osteon
Central Canal
Lamella
Lacuna
Central Canal
Blood vessels
Nerve fibers
Lamella
Rings around central canal
Lacuna
Where the osteocytes sit
Steps of intramembranous ossification
Mesenchymal cells differentiate into osteoblasts
Osteoids calcify- forming the bone matrix
Trabeculae and periosteum form
Trabeculae deep to periostium are replaced by compact bone- forming compact bone plates
Mesenchymal cells differentiate into osteoblasts
Osteoblasts start laying down matrix (collagen, osteoid) form ossification centers
Osteoids calcify- forming the bone matrix
Trapped osteoblasts turn into osteocytes
Trabeculae and periosteum form
Osteoid is laid down between embryonic blood vessels forming trabeculae
Vascularized mesenchyme condenses and becomes the periosteum
Trabeculae deep to periosteum are replaced by compact bone-forming compact bone plates
Spongy bone (diploe) persists inside
List the steps of endochondral ossification
Bone collar forms around the diaphysis of the hyaline cartilage model
Cartilage in the center of the diaphysis calcifies and then develops cavities
The periosteal bud invades internal cavities and spongy bone forms
The diaphysis elongates and a medullary cavity forms. Secondary ossification centers appear in the epiphysis
The epiphysis ossify. When completed, hyaline cartilage remains only in the epiphyseal plates and articular cartilages
Events in longitudinal bone growth
Resting (quiescent) zone Growth (proliferation) zone Hypertrophic zone Calcification zone Ossification