Exam 3 Respiratory Flashcards
What are the functions of the respiratory system?
- Air conduction/gas exchange
- Phonation
- Olfaction
- Heat Regulation
- Air conditioning
- protection
- Acid-base regulation
- Hormone conversion
How can the structures within the respiratory system be divided by function?
- conductive
- Transitional
- Gas exchange
What is the conductive system composed of?
nasal cavity pahrynx larynx trachea Bronchi
What is the Transitional system composed of?
Terminal bronchioles
What is the gas exchange system composed of?
Respiratory bronchioles
alveoli
what are the 4 main functions of the conducting system?
- Brings air to respiratory portion
- cleanses, moistens and warms incoming air
- blood in venous plexuses in mucous memb. of nasal cavity regulates temp. of inhaled air
- hair and secretions in the nasal cavity trap particulate matter
What is the transitional system?
A transition zone b/t the conducting and the gas exchange areas of the respiratory tree
What are the terminal bronchioles lined by?
- club cells
- non-ciliated secretory cells
- few ciliated cells
4 no goblet cells
Thin walled structures enveloped by a rich network of capillaries that make up the exchange system.
Alveoli
What are the capillaries called that make up the Alveoli
Pulmonary capillaries
What are the 2 cell types that line alveoli in the exchange system
1 epithelial type 1
2 type II pneumonocytes
Trace air flow through the respiratory tree.
Nasal cavity– Nasopharynx– Larynx– Trachea– Bronchi– Bronchioles– Exchange– Respiratory bronchioles– Alveolar ducts– Alveolar sacs– Alveoli
What are the 2 types of defense mechanisms of the respiratory system
- Non- specific
2. specific
What is another name for non specific defense mechanism
non immune mediated
What are the 4 ways of the non specific defense mechanism?
- Mucous trapping
- Mucociliary clearance
- phagocytosis
- Air turbulence
What is another name for specific defense mechanism?
immune mediated
What are the 3 ways of the specific defense mechanism
- Antibody production
- antibody-mediated phagocytosis
- cell-mediated immunity
What lines the respiratory portion of the nasal cavity?
pseudostratified columnar epithelium with goblet cells
What types of glands are found in the lamina propria
Tubulo-alveolar glands
What are the 3 regions of the nasal cavity?
- Vestibular region
- Respiratory Region
- Olfactory Region
The initial, external part of the nasal cavity, has a cutaneous mucous memb. haired skin, and glands
Vestibular region
What types of cells line the vestibular region of the nasal cavity
stratified squamous keratinized epithelium
what is the mucociliary apparatus?
The combination of columnar ciliated epithelium and goblet cells found in the respiratory region of the nasal cavity
projections in the respiratory region that narrow the lumen of the nasal cavity and inc. the area of contact of inhaled air with respiratory mucous memb.
Conchae Turbinates
How are ciliated epithelial cells connected
Gap junctions
What is immotile cilia syndrome
dynein claws missing from cilia
what type of cell lines the olfactory region of the nasal cavity?
olfactory epithelium with no goblet cells
What is thicker, olfactory epithelim, or respiratory epithelium?
olfactory
What are the 3 cell types found in the olfactory epithelium?
- Olfactory neurons
- Supporting/sustentacular cells
- Basal cells
What are swell bodies?
aka venous plecuses
found in olfactory and respiratory regions which re distended with blood
Which cranial nerve is found in olfactory region?
Cr N 1
What is the vomero-nasal organ?
Mainly used to detect pheromones
What cell type lines the Larynx
stratified squamous epithelium
after the vocal chords, what lines the larynx?
pseudostratified ciliated columnar epithelium
what cell type lines the trachea?
ciliated pseudostratified columnar epithelium
What cell type lines the bronchi?
Ciliated pseudostratified columnar epithelium
What do the glands of the bronchus secreate?
mucin, lactoferrin and lysozyme
T/F Bronchioles lack cartilage and glands
T
bronchi branch into _______
Bronchioles
What are the two subdivisions of bronchioles?
- Terminal
2. respiratory
What cell types line the terminal bronchioles?
Ciliated cuboidal cells with few to no goblet cells
What are club cells?
located in terminal and respiratory bronchioles that metabolize airborne toxins
What does respiratory bronchioles subdivide into?
alveolar ducts
Where do alveolar ducts empty into?
alveolar sacs and alveoli
What cell type lines the alveoli?
Simple squamous epithelial cells
Alveoli are lined by 2 distinct epithelial cells:
- Pneumocytes type I
2. Pneumocytes type II
What are alveolar pores of kohn?
Pores that connect neighboring alveoli that provides equalization of pressure and collateral ventilation if bronchiole is obstructed
Where are collagen type III fibers found?
Alveolar wall
where are collagen type I fibers found?
Conducting airways
What forms the walls of alveoli?
Pneumocyte Type I
Aka. Squamous Alveolar type I cell
Pneumocyte Type II
What are some features of Pneumocyte type I?
- Extremely thin
- occluding junctions to prevent fluid passage
- gas permeability
- not mitotic
What is Pneumocyte type II
account for 5% of alveolar SA
Secratory cell, produces surfactant, can be mitotic
What is surfactant?
Mono-molecular layer of phospholipoprotein that functions to reduce surface tension, reducing effort needed to inflate alveoli
What is the absence of surfactant in newborns known as?
Hyaline Membrane Disease
What are the 3 layers of the Air-Blood Barrier?
- Cytoplasm of pneumocyte type I covered by surfactant
- Two fused basal laminae of alveolar epithelium and endothelium of capillary
- Endothelium
Trace the passage of O2 through the air-blood barrier.
Surfactant– Cyto. fo type I alveolar cell– Basal Lamina of type I cell– Basal lamina of endothelial cell– Cyto. of Endothelial cell– Capillary RBCs
What are the two types of pulmonary macrophages?
- alveolar macrophages (PAMs)
2. Intravascular Macrophages (PIMs)
T/F. There are no lymphatic vessels in alveolar walls.
T
Covering of the lungs, composed of connective tissue and lined by simple squamous epithelium
Visceral pleura
Covering the thoracic wall, diaphragm, and mediastinum
Parietal pleura
Name of cells that compose the pleura
Mesothelial cells