Exam 3-7

Question 1

CML found on the

Answer 1

philadelphia chromosome

Question 2

RB is a _____ on the _____ chromosome. It can be detected by ________.

Answer 2

• tumor suppressor
• 13p14
• PCR and Southern blot

Question 3

retinoblastoma is caused by _______ and the inheritance pattern is _______.

Answer 3

• LOH

- auto dom

Question 4

____phosphorylation at S and G2. ____phosphorylationat G1 or G0

Answer 4

hyper, hypo

Question 5

APC gene in FAP is a ________ and found on chromosome ______

Answer 5

tumor suppressor, 5q

Question 6

FAP is caused by ____ and its inheritance pattern is ______. a common sign are _____

Answer 6

LOH, auto dom, colon polyps

Question 7

if APC is blocked, it cannot ________

Answer 7

degrade B-catenin and therefore c-myc is overexpressed

Question 8

CDKs

Answer 8

block RB (cant progress from G1 to S)

Question 9

E6

Answer 9

blocks p53

Question 10

E7

Answer 10

blocks RB

Question 11

BRCA 1 and 2 functions

Answer 11

DNA repair

found in breast cancers

Question 12

BRCA2 allelic with

Answer 12

FANCD1

Question 13

p53 is a _______ and acts as a _____ and is also important for apoptosis.

Answer 13

tumor suppressor, TF, apoptosis

Question 14

p53 is seen in _____-_____ mutations

Answer 14

dom-neg

Question 15

EB1

Answer 15

blocks p53