Exam 3-1

Question 1

Golgi functions (4)

Answer 1

• synthesis of sphingolipids
• proteolytic processing
• post-translational modification of proteins and lipids
• sorting of proteins and lipids for post-golgi compartments

Question 2

clathrin - moves from the

Answer 2

lysosome to the PM and back

Question 3

COPI - moves from the

Answer 3

golgi to the ER

Question 4

COPII - moves from the

Answer 4

ER to the golgi

Question 5

N-linked glycosylation

Answer 5

carbohydrate complex added to an aspraganine in the ER lumen

Question 6

multiple TM domains:

aa, CFTR and VGNa channels

Answer 6

12, 12, 24

Question 7

Type I TMD, COO- in the _______ and NH3+ in the _______

Answer 7

cytoplasm, ER lumen

Question 8

Type II TMD, COO- in the _______ and NH3+ in the _______

Answer 8

ER lumen, cytoplasm

Question 9

BiP

Answer 9

• chaperon
• luminal face
• binds protein through translocon and helps it fold

Question 10

SRP

Answer 10

signal recognition particle

Question 11

Nup 358/RanBP2

Answer 11

acute necrotic encephaly

hetero missense T585M

Question 12

Nup 62

Answer 12

primary biliary cirrhosis - autoimmune antigen & auto rec inflamm bilat striatal necrosis - homo miss Q391P

Question 13

Nup 98

Answer 13

AML
fusion with Nup 98
FG repeats

Question 14

Nup 155

Answer 14

AF

homozygous missense R391H

Question 15

Cowden Syndrome

Answer 15

PTEN is translocated by KapB

no NSL –> no translocation into the nucleus

Question 16

Male–> female sex reversal

Answer 16

importin B1 binds to SRY and translocates to nucleus

no NLS –> no translocation