Exam 3-10

Question 1

Calnexin

Answer 1

TMP, binds oligosaccharide and Ca2+

Question 2

calcreticulum

Answer 2

lumen protein, binds oligsaccharides and Ca 2+

Question 3

retrotranslocated protein

Answer 3

deglycosylated, polyubiq

Question 4

proteosome

Answer 4

central cyllinder cleaves, caps recognize polyubiq and uses ATP to unfold protein

Question 5

ubiquinine ligase enzymes

Answer 5

E1 binds and activates, E2, E3 substrate specificty leads to polyubiq

Question 6

lysosome lumen =

Answer 6

5 (due to H+ pump)

Question 7

necrosis

Answer 7

pumps fail, cell swells and busts leading to inflammation

Question 8

apoptosis

Answer 8

nucleus collapses, chromatin is super condenses and cell shrinks

Question 9

LAMP2A

Answer 9

where proteins go to be degraded, highly regulated

Question 10

autophagy has a __________ vehicle

Answer 10

double membrane

Question 11

autophagy cancer tx

Answer 11

combination of drugs

Question 12

protein is tagged with ______ and incripted into autophagosome membrane

Answer 12

lipids

Question 13

atg genes

1, 12 and 6

Answer 13

regulate autophagy

• 1 = protein kinase
• 12 = ubiq
• 6 = Beclin1 = scaffold