Exam 3-6 Flashcards
1
Q
HMGCoA is blocked by
A
statins
2
Q
SREBP
A
reg LDLR and synthesis proteins
3
Q
low cholesterol –>
A
SREBP TF releases
4
Q
SREBP is held in the ___ and cleaved in the ______
A
ER, golgi
5
Q
SCAP binds
A
SREBP and sterols
6
Q
insig binds
A
SCAP and increased cholesterol
7
Q
_______ carries SCAP to the golgi
A
COPII
8
Q
RIP proteins
A
S1P and S2P (need both to activate)
9
Q
cholesterol made of
A
polar OH group
steriod ring
hydrocarbon tail
10
Q
sphingolipids made of
A
- ceramide
- polar head group
11
Q
phospholipids made of
A
glycerol + 3P
polar head group
hydrocarbon tail
12
Q
erbB2
A
HER2/neu oncogene
found in breast cancers
can be reversed by Herceptin
13
Q
Gleevec
A
BRC-ABL
philadelphia chromosome
tyrosine kinase inhibitor
14
Q
Estrogen receptor is a(n)
A
oncogene
