Exam 3-5 Flashcards
1
Q
n-sec1
A
refolds syntaxin into active formation
2
Q
NSF and alpha-SNAP
A
disassemble protein
NSF uses ATP hydrolysis
3
Q
VAMP location
A
transport vesicle
4
Q
SNAP location
A
target membrane
5
Q
syntaxin location
A
target membrane
6
Q
HIF is a ____ that is _____ dependent.
A
TF
oxygen
7
Q
HIF-alpha is ______ by ___ and ___
A
hydroxylated by proline and aspraganine
8
Q
VHL _____ normal HIF-alpha
A
ubiq
9
Q
use _______ to target downstream GFs of HIF and ______ to target mTOR
A
Sāā-nib
______lumin
10
Q
VHL is a
A
tumor suppressor
11
Q
sign of VHL
A
hemangioloastomas
12
Q
Type 1, 2A and 2B ____regulate HIF
A
up
13
Q
Type 2C ____regulates HIF
A
down
14
Q
most VHL are
A
clear cell sporadid
15
Q
VHL chromosome and what else is on it
A
3p
also on this are BAP 1 and PRBM1
