Exam 3-13

Question 1

G-actin

Answer 1

form F-actin helices

Question 2

MFs

Answer 2

cell shape, movement and polarity

Question 3

phalloidin

Answer 3

drug that stabilizes f-actin

Question 4

AF nucleation occurs at the

Answer 4

PM

Question 5

ARPs: what is it and where does it start?

Answer 5

catalyze nucation of the MFs, starts at the neg end to rapidly polymerize at the plus end

Question 6

actins anchor

Answer 6

protein in junctions

Question 7

AJ proteins

Answer 7

cadherins and catenins

Question 8

actin is part of microvilli formation

Answer 8

apical protein cap –> + ends anchored, crosslinking with villin and fimbrin

Question 9

filopodia and lamellipodia

Answer 9

can adhere and detach from cell srtatum via adhesion molecules

Question 10

Rho fam

Answer 10

Rho (stress fibers and adhsions)
Rac (axon of veils)
Cdc42 (protrusion of filiopdia)

Question 11

chemokinesis

Answer 11

random migration action

Question 12

chemotaxin

Answer 12

directed migration

Question 13

protrusion involves

Answer 13

Ras and WAS

Question 14

diseases of actin-associated protein

Answer 14

WAS, lissencephaly, metastasis

Question 15

example of a node:

Answer 15

Ca2+

Question 16

example of modules:

Answer 16

protein complexes