Exam 3-16 Flashcards
1
Q
CAMs
A
when bound to a ligand have a conformational change, form TM link
2
Q
cadhedrin
A
single pass TM glycoprotein that operates as a homodimer, Ca2+ dependent
3
Q
IgSF
A
single pass TM glycoprotein, homophobic binding, no dimers, no Ca2+
4
Q
integrins
A
“classic” AMs, heterophilic, A/B heterodimer
5
Q
CAMS linked to cytoskeleton and also regulate
A
adhesion, control actin polymerization, mediate cell signaling
6
Q
in development, CAMs change as ___________
A
cells differentiate
7
Q
ECM and disease
A
- collagen= osteogenesis and skeletal dysplasias
- lamin= nephrotic syndrome and neuromuscular junction/muscular problems in children
- MMP - LOF mutations 2 or 13 = osteolysis/arthritis/bone diseases
8
Q
cell adhesion and disease
A
leukocyte adhesion
-type I - integrin, type 2 - selectin
cancer
