Exam 3-15

Question 1

parvalbumin = ______ buffer

Answer 1

cytoplasmic

Question 2

calsequestrin = _______ buffer

Answer 2

ER/SR

Question 3

Calmodulin

Answer 3

binds to and confers Ca2+ regulation to large number of other proteins (L hand motif found in parvalbumin, calpain and troponin)

Question 4

cytopalnine

Answer 4

cancer drug that kills cancer and stem cells

Question 5

abiraterone acetate

Answer 5

CMP17 inhibitor that decreases testosterone levels

Question 6

enzalutamide

Answer 6

new generation AR antagonist

Question 7

GAGs

Answer 7

covalent linkage to proteins –> proteoglycans

• amno sugar + uronic acid
• high neg charge

Question 8

fibrolyproteins

Answer 8

elastin

Question 9

multiclonar adaptor proteins

Answer 9

fibronectin and laminin

Question 10

PGs

Answer 10

high molecular weight, core proteins = serine, tetrasaccharides, filtering of glomerulus and reservoir or GF and proteases

Question 11

Aggrecan

Answer 11

assembly of PGs and GAGs

Question 12

collagens I and IV

Answer 12

I connective tissues, IV = basal lamina

Question 13

fibronectin =

Answer 13

dimeric glycoprotein, S-s, Arg-Gly-Asp, forms fibrils

Question 14

laminin

Answer 14

3 subunits (ABG) S-S, basal lamina, self assembly

Question 15

MMP function

Answer 15

turn over ECM