Exam 1; Specific Periodontal Pathogens Flashcards

1
Q

What three things are involved with association of AA

A

high numbers are associated with aggressive periodontitis
detected in active sites
detected in prospective studies

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2
Q

What two things involve the elimination of A

A

elimination or suppression resulted in successful therapy

recurrent lesions harbor the species

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3
Q

What is the host response to AA

A

high levels of systemic and antibody response

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4
Q

What are the five virulence factors of AA

A
tissue invasion
leukotoxin
fibroblast inhibiting factor
endotoxin
collagenase
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5
Q

What commercial bacteria does AA inhibit the growth of

A

S. sanguis

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6
Q

What are two components of the evidence against AA as a pathogen

A

not seen in all cases of aggressive periodontitis

seem in periodontally healthy patients

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7
Q

AA with the 530 bp deletion is how much more likely to be disease-associated than AA with the full length promotor region

A

23x

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8
Q

What differs between the serotypes of AA

A

polysaccharides on surface of organism

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9
Q

What is the dominant antigen in AA

A

serotype specific surface antigens

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10
Q

True or False

Patients are infected with multiple serotypes of AA

A

False; they are only infected with one

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11
Q

Which AA serotype is the most commonly associated with localized aggressive periodontitis in USA

A

B

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12
Q

AA has a role in resistance to what and killing by what

A

resistance by phagocytosis

killing by PMNs

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13
Q

What two approaches are vital to treatment involving AA

A

mechanical and chemotherapeutic approaches

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14
Q

This approach may be used to eliminate tissue reservoirs of AA

A

surgical

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15
Q
The pathogen is
gram negative
anaerobic
non-motile
asacharolytic rods
black pigmented bactericides
producing collagenases, proteases, hemolysins, endotoxin, fatty acids, NH3, H2S, and indole
A

Porphyromonas gingivalis

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16
Q

This component of P. gingival is in important in protein degradation and in the maturation of cell surface proteins such as fimA fimbrillin

A

cysteine proteinases

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17
Q

What four things are involved with association with Pg

A

elevated in lesions of periodontitis
lower in healthy sites and subjects
elevated in progressing lesions
presence indicated increased risk for attachment loss

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18
Q

What three things are involved with elimination of Pg

A

elimination results in successful therapy
recurrent lesions harbor organisms
successful therapy lowered antibody level

19
Q

What is the host response to Pg

A

elevated antibody in serum/saliva of subjects with periodontitis

20
Q

What four things attribute to evidence against Pg as a pathogen

A

seen in health
not always seen in disease
high antibody response
not numerous in the sub gingival community

21
Q
This pathogen is
gram-negative
anaerobic
spindle-shaped
highly pleomorphic rod
requires NAM***
co-cultivates with F. nucelatum
A

tannerella forthysia

22
Q

What does the serrated S layer of T. forthysia do

A

mediates adhesion

hemagglutination

23
Q

What four things are involved with the association of Tf

A

elevated in lesions of periodontitis
lower in healthy sites and subjects
elevated in progressing lesions
presence indicated increased risk for attachment loss

24
Q

What three things are involved with elimination of Tf

A

elimination results successful in therapy
recurrent lesion harbor organism
reduced in successfully treated peri-implantitis

25
Q

What is the host response to Tf

A

elevated antibody in serum/saliva with refractory periodontitis

26
Q

What are two virulence factors of Tf

A

several factors

invades epithelial cells in vitro

27
Q
These pathogens are
gram-negative
anaerobic
helical-shaped
1st identified in ANUG
there are several different species, hard to distinguish
A

Trepanema denticoli

28
Q
These pathogens are
gram-negative
short, round ended rod
anaerobic
black pigmented Bacteriodes
luxuriant growth in naqhthoquinone (steroids are high in this)
associated with puberty/pregnanvy gingivitis
elevated in NUG
A

Prevotella intermedia/nigrescens

29
Q

What are three pieces of evidence backing-up why Prevotella intermedia/nigrescens is pathogenic

A

seen in progressing sites
demonstrated in intercellular spaces
induces alveolar bone loss in rats

30
Q

Sites with Pi/Pn show persistent what

A

BOP

31
Q

What decreases BOP and Pi/Pn levels

A

amox + metro

32
Q

Pi/Pn release want in pockets

A

MMP-8 and MMP-9

33
Q
This bacteria is
gram -
anaerobic
spindle-shaped rod
early colonizer in the plaque
bridging organism
A

fusobacterium nucleatum

34
Q

This is the most common isolate cultured from sub gingival microbiota in health and disease

A

F. nucleatum

35
Q

What does F. nucleatum do to leukocytes

A

induce cell death

releasing cytokines, elastases, and oxygen radical from leukocytes

36
Q
This pathogen is
gram -
anaerobic
short
motile vibrio
A

Campylobacter rectus

37
Q
This pathogen is
gram -
capnophilic
assacharoltyic
regular
small rod with blunt ends
A

Eikenella corrodens

38
Q
This pathogen is
gram +
anaerobic
small
assacharolytic coccus
A

Peptostreptococcus micros

39
Q

This pathogen is
gram -
curved
saccharolytic rods

A

Selenomonas species

40
Q
This pathogen is
gram +
anaerobic
small
pleomorphic rods
A

Eubacterium species

41
Q

This serotype of AA is found in health in Finland but disease in Japan

A

A

42
Q

What is the main virulence factor of P. gingivalis

A

gingipans

43
Q

What are the three organisms in the “red complex”; these that cause chronic periodontitis

A

P. G.
T. F.
T. D.
AA is not apart of this, it causes a specific disease