Exam 1; Pathogenesis of Periodontitis Flashcards
This is attached to enamel
the junctional epithelium
This appears to be continuous with the junctional epithelium
oral epithelium
What are the tissue ratios in healthy gingiva
10% JE
30% OE
60% CT
True or False
There is a large number of PMNs present in the outer portion of the JE
False; there are only a few
What is the thickness of the JE
thin; 10-20 cell layers thick
What is absent in the gingiva
epithelial ridges; rete pegs
This is dense with prominent collagen fiber bundles
connective tissue
This is with capillary loops (rete pegs) and the number of loops is constant
subepithelial plexus
The anastomoses of supraperiosteal blood vessels (sv) is with what
vessels from the bone and PL
These have no loops in healthy gingiva
dentogingival plexus (dp)
What are 6 reasons for stability in healthy gingiva
shedding of epithelial cells intact epithelial barrier positive flow of the GCF complement system PMNs and macrophages protective effects of antibodies
Histopathological stages in the development of gingivitis and periodontitis were described by who
Page and Schroeder
This lesion stage is in the sub gingival stage of gingivitis
initial lesion
This lesion stage is in the clinical stage of gingivitis
early lesion
This lesion stage is chronic gingivitis
established lesion
This lesion stage is in the progression of periodontitis
advanced lesion
This type of lesion occurs within 1-4 days of plaque development and has the early stage of inflammation
initial lesion
The initial lesion has increased permeability and infiltration to which molecules
permeable to; carbon particles and serum proteins that leak out of vessels
PMNs and monocytes in the JE and lymphocytes in the CT
This type of lesion has increased vascular density, decreased perivascular collagen, and increased gingival crevicular fluid
initial lesion
Is the initial lesion detectable clinically
No
Where do the vessels dilate in the initial lesion, resulting in increased permeability and an increase in GCF flow
dentogingival plexus
What is vasodilation induced by in the initial lesion
vasoactive mediators like histamine, IL-1, TNF
This is a plasma transduate (health) and inflammatory exudate (disease)
GCF
GCF constituents indicate what
inflammatory changes and bacterial colonization
Does GCF flow rate increase or decrease with clinical inflammation
increase
This stain is for protein indicates GCF volume
ninhydrin
There is cytokine-mediated up-regulation of this in the initial lesion
adhesion molecules on endothelial cells
These adhere to post-capillary venues and begin to migrate through the JE into the gingival sulcus
PMNs
Chemotaxis by PMNs is induced by what two things
host factors (IL-8, C5a) molecules released by bacteria