Exam 1 9/15 Davenport Bone Flashcards
Definition of bone
connective tissue characterized by a mineralized extracellular matrix
Osteocytes in _____ with _____
lacunae; canaliculi
Bone cell types
osteocytes, osteoprogenitor cells, osteoblasts, osteoclasts
Two types of bone
spongy bone, compact bone
Describe spongy bone
- Similar to adult compact bone except that tissue is arranged as trabecular or spicules
- numerous interconnecting marrow spaces
- matrix is lamellated
Mature bone
Adult; has lamellar pattern
Immature bone
Initially deposited bone, non-lamellar, more cells per unit area and more randomly arranged, matrix has more ground substance
True false: bone is highly vascularized
True - no osteocyte is more than 300 microns from a blood vessel
Bone blood supply is ______
Centrifugal
Another name for spongy bone
Cancellous, trabecular
Bone is covered by:
Periosteum - sheath of dense connective tissue
Periosteum is made of:
osteoprogenitor cells, periosteal cells (potential osteoblasts), Sharpey’s fibers
Bone marrow cavity is lined by:
endosteum (more delicate layer of CT)
Endosteum is made of:
osteoprogenitor cells, endosteal cells (potential osteoblasts)
Mature bone is composed of structural units called:
Osteons
Another name for osteons
Haversian systems
Osteon structure
Osteon canal in the center, canaliculi around it, osteocyte in lacuna around periphery
Volkmann canals
Connect Haversian canals together
What happens when minerals are removed?
Fibers still form the same structure, but strength is decreased
Initial appearance of bone occurs around:
Blood vessel
Osteoclast derived from:
macrophage (resorbs mineralized bone)
True or false: if you see osteoclasts, there would be no presence of osteoblasts nearby
False - osteoblasts found near osteoclasts to help balance out how much bone is there
Osteoprogenitor cell is derived from:
Mesenchymal cell lineage
Mesenchyme is precursor for:
mesoderm
Osteoprogenitor cell
Resting cell that can transform into an osteoblast and secrete bone matrix
How do osteoblasts/osteocytes communicate?
Gap junctions
Osteoblast
A differentiated bone forming cell that secretes bone matrix
Osteocytes
Mature bone cells enclosed by bone matrix that was secreted when it was an osteoblast
Osteocytes reside in:
Lacunae (processes extend into canaliculi
3 functional states of osteocytes
- quiescent
- formative
- resorptive
Osteoclast releases _____ into extracellular space
lysosomes
True or false: osteoclasts are phagocytic
True
Bone serves as a reservoir for:
calcium
What hormones do bone respond to to help maintain blood calcium levels?
Parathyroid hormone; calcitonin
Somatotropin
Pituitary growth hormone - stimulates growth in general as well as growth of the epiphyseal cartilage and bone
Oversecretion of somatotropin results in:
giantism; leads to acromegaly as an adult
Hyposecretion of somatotropin results in:
Dwarfism
Thyroid hormone
Hyposecretion in infancy and childhood results in cretinism
Cretinism
failure of bone growth and dwarfism