EPILEPSY: SIDE EFFECTS Flashcards
AEDs SFx general
Depression + suicide
Hepatotoxicity
Hypersensitivity: CPPPLamo
Blood dyscrasia: C,V,E,T,Phen,Lamo,Z (C VET PLZ)
Vit d def
Skin rash e.g. stevens-johnsons syndrome: lamotrigine
Eye disorder
o Vigabatrin (reduces visual field)
o Topiramate (secondary glaucoma)
Encephalopathy: Vigabatrin
Respiratory depression: Gabapentin, pregabalin
Which drugs interact with AEDs to cause hepatotoxicity?
amiodarone
itraconazole
macrolides (mycins)
alcohol
Which AEDs are CYP enzymes INDUCERS?
carbamazepine
phenytoin
phenobarbital
Phenytoin as an enzyme inducer
Reduces conc of
- hormonal concentreptive/ HRT
- warfarin
- levothyroxine
Causes increased antifolaxe effect with methotrexate and trimethoprim
Which drugs interact with AEDs to lower seizure threshold?
o Tramadol
o Theophylline
o Quinolones
What AEDs cause blood dyscrasia?
Carbamazepine
Valproate
Ethosuxidimide
Topiramate
Phenytoin
Lamotrigine
Zonisamide
C VET PLZ
Which AED reduces visual field?
Vigabatrin
Which AED causes encephalopathy?
Vigabatrin
Which AED can cause secondary glaucoma
topiramate
Which AEDS can cause respiratory depression
Gabapentin
Pregabalin
SV: side effects
Hepatotoxicity
Blood disorders
Pancreatitis
Drugs that antagonise the anticonvulsant effect of sodium valproate
Quinolone
Mefloquine
SSRIs
Antipsychotics
TCA/related antidepressants
Drugs that increase the risk of hepatoxicity with sodium valproate
Statins
Carbamazepine
Tetracyclines
Fluconazole
Isoniazid
Itraconazole
Methotrexate
Sulfasalazine
Sodium valproate increases the concentration of what drugs?
Enzyme inhibitors = increases the drug concentration of other anti-epileptic drugs e.g. lamotrigine, phenobarbital
