EPILEPSY: OTHER AED DRUGS Flashcards
1
Q
Ethosuximide - Indication
A
- Absence
* Adjunct in atypical
* Myoclonic
2
Q
Ethosuximide - major side effect
A
Blood disorder
3
Q
Gabapentin - safety information
A
- Levels of propylene glycol, acesulfame K and saccharin sodium may exceed the recommended WHO daily intake limits
- high doses of gabapentin oral solution (Rosemont brand) are given to adolescents or adults
- low body-weight (39–50 kg).
4
Q
Topiramate - indication
A
- T-C
- F
- Myo
5
Q
Topiramate - SEs
A
- DN / weight loss decreased appetite
- Drowsiness
- Altered mood
- VISION
6
Q
Topiramate - other uses
A
Migraine prophylaxis
7
Q
Topiramate - cautions
A
- Acute porphyrias
- Risk of metabolic acidosis
- Risk of nephrolithiasis (kidney stones)
8
Q
Topiramate - preventing kidney stones
A
- Adequate hydration
9
Q
Topiramate - important side effect
A
- Acute myopia (short-sightedness) with secondary angle-closure glaucoma.
- 1 month of starting treatment.
- Fluid build-up resulting in anterior displacement of the lens and iris has also been reported.
10
Q
Topiramate - raise intraocular pressure
A
Seek specialist ophthalmological advice.
Appropriate measures to reduce intra-ocular pressure.
Stop topiramate as rapidly as feasible.
11
Q
Topiramate - contraception
A
PPP
* increased risk of autism, ADHD and intellectual disability
12
Q
Can topiramate be taken during pregnancy?
A
- If for migraine prophylaxis, then no
- If epilepsy, then yes if no other option
- Extra monitoring required e.g. fetal growth
13
Q
Can you take
topiramate whilst breastfeeding?
A
- Yes
- Monitor ADRs in children
14
Q
Vigabatrin - indication
A
- Focal - not controlled by other drugs
- Expert only
15
Q
Vigabatrin - SE
A
Visual field effects
Encephalopathic symptoms - sedation confusion
