DEMENTIA: DONEPEZIL Flashcards
1
Q
Donepezil
A
Ach-esterase inbibitor
2
Q
Indication
A
Mild to moderate dementia in Alzheimer’s disease
3
Q
Donepezil - dose
A
initally 5mg OD for one month
increase if necessary to 10mg OD
to be taken at night
4
Q
Donepezil - administration instructions
A
nocte
5
Q
Donepezil - cautions
A
Cardiac conduction disorder
Asthma
COPD
sick sinus syndrome
SV conduction abnormalities
susceptibility to peptic ulcers
6
Q
Donepezil - side effects
A
Neuroleptic malignant syndrome
EPSEs
diarrhoea, GI disorders, nausea, vomiting
7
Q
When does risk of neuroleptic malignant syndrome increase?
A
Risk increased with concomitant antipsychotics
8
Q
Donepezil - interactions
A
beta blockers
RL CCBs
anti-arrhtyhmics e.g. dronedarone, amiodarone, fleicanide
digoxin
