DEPRESSION: SEROTONIN SYNDROME Flashcards
1
Q
What is serotonin syndrome?
A
Serotonin toxicity caused by excessive central and peripheral serotonergic activity.
2
Q
What drugs cause serotonin syndrome?
A
St. Johns wort (serotonergic antidepressant)
Amfetamines
Sumatriptan (5-HT1a agonist)
Selegiline (MAO-B inhibitor)
Tramadol (opioid that also inhibits reuptake of 5-HT + NA)
TCAs/MAOIs (serotonergic drugs)
Ondansetron (5-HT3 antagonists)
3
Q
What are the effects of serotonin syndrome?
A
Cognitive effects
Autonomic effects
Neuromuscular excitation
4
Q
Cognitive effects
A
headache
agitation/confusion
5
Q
Autonomic effects
A
sweating/shivering
D+N
tachycardia
6
Q
Neuromuscular excitation
A
Tremor
Myoclonus
Teeth grinding
Hyperreflexia
