EPILEPSY: PHENOBARBITAL + PRIMIDONE Flashcards
1
Q
What is primidone converted to once metabolised?
A
- Partially converted to phenobarbital
2
Q
Primidone - indications
A
- All forms of epilepsies except absence seizures
- Essential tremor
3
Q
Phenobarbital - indications
A
- All forms of epilepsy
- SE
4
Q
Phenobarbital - cautions
A
- Acute P
- History of drug/alcohol abuse
- Resp dep
5
Q
Phenobarbital - SE
A
- MAIN: drowsiness/sedation
- Agranulocytosis
- depression
- folate def
- memory loss
- thrombocytopenia
- SCARs
- hypotension
- resp dep
MATHS RF
6
Q
Phenobarbital - monitoring
A
- Plasma - phenobarbital conc
- 15-40mg/L
7
Q
Phenobarbital - Schedule
A
3
not in cup
8
Q
Dose eq for phenobarbital/ sodium
A
=
9
Q
Can you switch between brands for phenobarbital
A
no
specific brand
10
Q
Phenobarbital - CPCS
A
- yes
- Only Sch 3 you can give
- max 5 days
11
Q
Phenobarbital - interactions
A
Inducer
* Decrease drug conc levels of many drugs which are metabolised by CYP enzymes
12
Q
Phenobarbital - contraception
A
- Use highly effective contraception
- COC + POP are not effective
13
Q
Can Phenobarbital be administered whilst breastfeeding?
A
- Avoid
- Likely to cause drowsiness in the baby
- This also applies to primidone as well
14
Q
Which barbiturates are short-acting?
A
- Thiopental sodium (used in anesthesia)
15
Q
Which barbiturates are intermediate-acting?
A
- Amobarbital
- Butobarbital
- Secobarbital
