DEMENTIA: GALANTAMINE

Question 1

GALANTAMINE MOA AND DRUG CLASS

Answer 1

Ach-esterase inbibitor
reversible inhibitor of Ach-esterase and also has nicotinic receptor agonsit properties

Question 2

GALANTAMINE DOSE
dose in mild to moderately severe dementia in AD

Answer 2

IR PREPS
initally 4mg BD for 4 weeks
increase to 8mg BD for at least 4 weeks
maintenane 8-12mg BD

Question 3

GALANTAMINE DOSE
dose in mild to moderately severe dementia in AD -

Answer 3

MR CAPSULES
initally 8mg OD for 4 weeks
increased to 16mg OD for at least 4 weeks
maintenance 16-24mg daily

Question 4

Avoid in

Answer 4

GI obstruction
Urinary outflow obstruction
whilst recovering from bladder surgery
whilst recovering from GI surgery

Question 5

GALANTAMINE: SFX

Answer 5

Steven-Johnson Syndrome,
Severe cutaneous adverse reactions (SCARs) – signs of skin reactions

Question 6

Interactions with galantamine - increased risk of bradycardia with

Answer 6

betablockers
anti-arrhythmics
digoxin