DEMENTIA: RIVASTIGAMINE

Question 1

Rivastigamine

Answer 1

Ach-esterase inhibitor
a reversible non-competitive inhibitor of Achesterase

Question 2

What RIVASTIGAMINE FORMULATION is licensed in mild to moderate dementia in Parkinsons disease

Answer 2

rivastigmine caps or oral solution

Question 3

if treatment with rivastigmine by mouth is interrupted for more than several days, what do you do

Answer 3

re titrate from 1.5mg BD .

Question 4

which RIVASTIGAMINE FORMULATION is not licensed for Parkinson’s disease dementia

Answer 4

Patches [unlicensed]

Question 5

if treatment with rivastigmine PATCHES is interrupted for more than 3 days , what do you do?

Answer 5

need to re titrate from lowest strength patch (4.6mg/24h).

Question 6

RIVASTIGAMINE: SFX (PO)

Answer 6

confusion
gait abnormal
hallucinations
hyperhidrosis
hypersalivarion
malaise
parkinonism
sleep disorders

Question 7

RIVASTIGAMINE: INTERACTIONS

Answer 7

RL CCB
BB
anti-arrhtyhmics
digoxin

Question 8

RIVASTIGAMINE: CAUTIONS

Answer 8

asthma
copd
peptic, duodenal, gastric ulcers
bladder outflow obstruction
sick sinus syndrome
susceptibility to ulcers

Question 9

RIVASTIGMINE: MONITORING

Answer 9

o SFx: GI SFx
o Stop if pt becomes dehydrated from prolonged vomiting or diarrhoea
o Less SFx with transdermal administration
o Monitor body weight