DEPRESSION: TCAs (new) Flashcards
1
Q
What are the side effects of
mirtazapine?
A
- Sedation
- Weight gain
- Blood disorders (Blood dyscrasias)
2
Q
If blood dyscrasia (blood disorder) is suspected whilst Mirtazapine, what should be done?
A
FBC
STOP
3
Q
What are the cautions for Mirtazapine?
A
- Cardiac disorders
- Diabetes
- History of mania (AVOID if manic)
- History of seizures
- Psychoses (may aggravate it)
4
Q
What time of day should mirtazipine be taken?
A
Nocte
5
Q
TCAs examples
A
- Amitriptyline
- Nortriptyline
- Clomipramine
- Imipramine
- Lotepramine
- Dosulepin
- Trazadone (TCA related)
6
Q
TCA MOA
A
- They block the uptake of both serotonin and
noradrenaline - Different types of TCAs vary in to the extent they block
7
Q
Which TCA is more selective for serotonergic transmission, Clomipramine or
Imipramine?
A
Clomipramine
8
Q
Which TCA is more selective for noradrenergic transmission
Clomipramine or
Imipramine?
A
Imipramine
9
Q
What are the side effects of TCAs?
A
- Antimuscarinic side-effects
- Sedation
- Cardiotoxicity (in overdose)
- QT prolongation
- Seizures
10
Q
Why are TCAs not commonly used?
A
- They are reserved for when SSRIs or Mirtazapine doesn’t work
- Less tolerated due to side-effects
- Riskier in overdose (e.g. cardiotoxicity)
11
Q
Which TCA’s are most sedating?
A
- Amitriptyline
- Clomipramine
- Dosulepin
- Trazadone
12
Q
Which TCAs are less sedating?
A
- Nortriptyline
- Lofepramine
- Imipramine
13
Q
Which TCA has the most antimuscarinic side-effect in comparison to other
TCAs and
antidepressants?
A
Imipramine
14
Q
A
.
15
Q
Which TCA is more dangerous in overdose in comparison to others?
A
- Dosulepin
- Amitriptyline
