Enzyme Inhibition

Question 1

Competitive enzyme inhibition

Answer 1

Binding to the same active site as the substrate

Question 2

How can competitive inhibition be overcome

Answer 2

Can be overcome by increasing [S]

because binding of inhibitor is dynamic (can be dissociated)

Question 3

Non-competitive enzyme inhibition

Answer 3

Binds to another DISTINCT binding site to influence affinity of enzyme binding site

Question 4

Process of enzyme inhibition (how it leads to less product)

Answer 4

Enzyme can bind to the substrate + the inhibitor simultaneously
Inhibitor not occupying the substrate specific active site
Increasing [S] = no effect on inhibitor
Presence of inhibitors = less enzyme available to catalyse the reaction = less product