ENDOCRINE- DOPAMINE + GONADOTROPHIN Flashcards
What is tx for endometriosis?
Danazol
Function of Gonadotrophin?
Causes pituitary gland in brain to make LH + FSH.
This makes testosterone + oestrogen, progesterone.
What other condition is Danazol used in?
Relief of severe pain + tenderness in benign fibrocystic breast disease.
If other methods fail.
What is a condition danazol is unlicensed in?
hereditary angioedema
Long term treatment
List 2 LH releasing hormone antagonists?
Cetrorelix and ganirelix
What are Cetrorelix and ganirelix used in?
Treatment of infertility
What 6 conditions are Gonadorelin analogues used in?
-Endometriosis
-Precocious puberty
-Infertility
-Male hypersexuality with severe sexual deviation
-Anaemia due to uterine fibroids (together with iron supplementation)
breast cancer, prostate cancer + before intra-uterine surgery
What are Gonadorelin analogues given with in anaemia?
Iron supplements
Use of leuprorelin acetate and triptorelin for 3 to 4 months before surgery helps do what?
Reduce fibroid size, uterine volume + reduces bleeding
What is tamoxifen used in?
Adjunct in the treatment of mastalgia
When should treatment for breast pain be reviewed?
Every 6 months + continue if needed.
Symptoms recur in about 50% of women within 2 years of withdrawal.
What are 3 natural oestrogen?
Estradiol
estrone
estriol
What are 2 fake oestrogen?
ethinylestradiol
mestranol
What is tibolone?
Both oestrogenic, progestogenic + weakly androgenic
What 3 menopausal symptoms do oestrogen with progesterone help?
Atrophy of vagina
Vasomotor instability
Osteoporosis
