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PRE-REG-Thuri > ENDOCRINE- ANTIDIURETIC HORMONE DISORDERS > Flashcards

ENDOCRINE- ANTIDIURETIC HORMONE DISORDERS Flashcards

1
Q

What is diabetes insipidus?

A

Different to DM.

Reduced production of ADH means kidney not retaining much water.

Can cause polyuria + polydipsia (thirst)

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2
Q

What is treatment for
CRANIAL diabetes insipidus?

A

Desmopressin - or drinking more water.

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3
Q

What is treatment of nephrogenic Diabetes insipidus?

A

Thiazides (paradoxical effect)

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4
Q

What is cause of nephrogenic Diabetes insipidus?

A

Kidneys do NOT respond to the ADH

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4
Q

What is cause of CRANIAL diabetes insipidus?

A

Hypothalamus/ pituitary does not make ENOUGH ADH.

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4
Q

What is MOA of desmopressin?

A

synthetic analogue of vasopressin (ADH)

Causes less urine

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5
Q

What does increase in ADH do to urine output?

A

Reduced urine output - less water released.

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6
Q

What are 2 advantages of desmopressin?

A

Longer duration of action

No vasoconstrictor effects

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7
Q

What is use of desmopression?

A

Diabetes insipidus

Nocturnal enuresis

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8
Q

What are 2 SEs of desmopression?

A

Hyponatraemia

Oedema

Nausea

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9
Q

What are 3 cautions of using desmopressin (oedema)?

A

caution in patients who have HTN, HF, Migraine.

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9
Q

What are 3 symptoms of Hyponatraemia?

A

Headache

N+ V

convulsions

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10
Q

What is a caution of using desmopressin (Hyponatraemia)?

A

Caution in elderly + epilepsy

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11
Q

What drug increases ADH secretion?

A

TCA

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12
Q

What 4 drug classes can interact with Desmopressin to cause hypOnatraemia?

A

TCA, Diuretcs, NSAID, SSRI

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13
Q

What is syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

A

HypOnatraemia caused by inappropriate ADH secretion = dilute salt in blood as urine not passed out.

14
Q

What are 2 treatment drugs for SIADH?

A

1.fluid restriction:

  1. Demeclocycline
  2. Tolvaptan
15
Q

What is Demeclocycline moa?

A

Blocks renal effect of ADH - causes Diabetes insipidus.

16
Q

What is tolvaptan class?

A

V2 receptor antagonist

17
Q

What is MOA of tolvaptan?

A

rapid correction

helps increase sodium concentration, reduce urine osmolatiry

18
Q

Why to avoid rapid correction of hyponatraemia with tolvaptan?

A

Causes osmotic demyelination

neurological events

19
Q

What electrolyte to avoid causing with tolvaptan?

A

avoid hyponatremia.

20
Q

How is urine concentration in Diabetes insipidus?

A

More dilute urine

PRE-REG-Thuri (44 decks)

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