ENDOCRINE- CORTICOSTEROIDS + CONDITIONS Flashcards
What is MOA of corticosteroids?
Synthetic version of hormones made by adrenal gland.
e.g. aldosterone , cortisol
What is aldosterone?
mineralocorticoid
What is cortisol?
Glucocorticoid
What is use of corticosteroids?
Inflammation + as an immunosuppressant
What are 2 routes of corticosteroids
Systemic e.g. oral
Local e.g. inhaled, topical + rectal
List 8 corticosteroids?
Betamethasone
Deflazacort
Dexamethasone
Fludrocortisone
Hydrocortisone
Methylprednisolone
Prednisolone
Triamcinolone
What 4 conditions are prednisolone used for?
Atsthma
COPD
Excema
IBD
What is dexamethasone usually used in?
Palliative care, anorexia
raised intracranial pressure
What is fludrocortisone used for?
Replacement therapy of aldosterone
mineralocorticoid
What is hydrocortisone?
replacement of cortisol
What are the 2 mineralocorticoid effects on electrolytes?
Na+/fluid retention = HTN + oedema caused
K+ excreted = HypOkalaemia + hypERcalcaemia
What is the most potent mineralocorticoid?
Fludrocortisone
What are 2 indications of
Fludrocortisone?
Neuropathic postural hypotension
Septic shock
What is hydrocortisone used in?
Acute hypersensitivity
Adrenal insufficiency
What are glucocorticoid effects?
Anti-inflammatory , low fluid retention
What 2 drugs are the most potent glucocorticoids?
dexamethasone
Betamethasone
What steroid has Significant mineralocorticoid activity?
Hydrocortisone
What 2 drugs are prednisolone derivatives?
Methylprednisolone
Deflazacort
What is a main SE of corticosteroid?
obesity
What are 3 endocrine SE of corticosteroids?
- Diabetes
- Cushing’s syndrome
- Growth failure in children
What 2 things to monitor children on steroids?
Height + Weight
What are 2 musculoskeletal SEs of corticosteroids?
Muscle wasting
Osteoporosis
What to give patients to prevent osteoporosis?
Bisphosphonates
What are 2 cautions in muscle wasting due to steroids?
Caution in patients on statins
Caution - myasthenia gravis
What are 2 GI SEs of corticosteroids?
Peptic ulcers
GI irritation + bleeding
What 4 counselling points to tell patient on steroids?
Take in morning- to avoid insomnia
Take with or after food - prevent GI irritation
Report psychiatric symptoms
Avoid contact with measles, chicken pox
What 2 CNS SEs of steroids?
Psychiatric reactions
Insomnia
What are 3 Skin related SEs of steroids?
Skin thinning
Purple red striae - stretch marks
Bruising