ED: Drug Interactions and Reactions

Question 1

Induction of P-450 enzymes

Answer 1

Quinidine, Barbiturates, St. John’s wort, Phenytoin, Rifampin, Griseofulvin, Carbamazepine

Question 2

Inhibition of P-450 enzymes

Answer 2

Cimetidine, ketoconazole, INH, grapefruit, erythromycin, sulfonamides

Question 3

Metabolism by P-450 enzymes

Answer 3

Benzodiazpines, amide anesthetics, metoprolol, propranolol, nifedipine, phenytoin, quinidine, theophylline, warfarin, barbiturates

Question 4

Increase risk of digoxin toxicity

Answer 4

Quinidine, cimetidine, amiodarone, calcium channel blockers

Question 5

Competition for albumin-binding sites

Answer 5

Warfarin, ASA, phenytoin

Question 6

Blood dyscrasias

Answer 6

Ibuprofen, quinidine, methyldopa, chemotherapeutic agents

Question 7

Hemolysis in G6PD-deficient patients

Answer 7

Sulfonamides, INH, ASA, ibuprofen, nitrofurantoin, primaquine, pyrimethamine, chloramphenicol

Question 8

Gynecomastia

Answer 8

Sprinolactone, estrogens, digitalis, cimetidine, chronic alcohol, ketoconazole (some excellent drugs create awesome knockers)

Question 9

Stevens-Johnson syndrome

Answer 9

Anticonvulsants, sulfonamides, penicillins

Question 10

Photosensitivity

Answer 10

Tetracycline, amiodarone, sulfonamides

Question 11

Drug-induced SLE

Answer 11

Procainamide, hydralazine, INH, penicillamine, chlorpromazine, methyldopa, quinidine