DNA replication Flashcards

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1
Q

Describe the structure of DNA

A

double helix
sugar phosphate back bone
4 nitrogenous bases

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2
Q

name the 4 nitrogenous bases

A

1) Adenine
2) guanine
3) cytosine
4) Thymine

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3
Q

how many hydrogen bonds join Adenine and thymine and what are they?

A

2

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4
Q

how many hydrogen bonds join cytosine and guanine and what are they?

A

3

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5
Q

The 2 strands of DNA run in what direction?

A

antiparallel

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6
Q

which end is a nucleotide added to a growing DNA strand?

A

3 prime

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7
Q

where does the energy come from to form the phospodiester bond between the nucleotides?

A

a nucelotide triphosphate - releases 2 phosphates

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8
Q

where does replication start in DNA?

A

at the origin of replication

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9
Q

what is the function of the enzyme topoisomerase?

A

corrects overwinding ahead of replication forks

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10
Q

what is the function of helicase?

A

untwist the DNA at the replication forks

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11
Q

what is the function of primase?

A

serves as a starting point for DNA synthesis by synthesising a short RNA primer

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12
Q

what is the function of DNA polymerase lll?

A

catalyses synthesis by pulling the DNA strand through the enzyme

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13
Q

what are the sections of DNA called in the lagging strand?

A

okazaki fragments

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14
Q

what is the function of DNA polymerase l?

A

replaces the RNA primer with DNA nucleotides

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15
Q

what joins together the okazaki fragments?

A

DNA ligase

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16
Q

what are telomeres?

A

nucleotide sequences which don’t contain genes so prevent the shortening of DNA

17
Q

how is DNA packed into bacterial chromosomes?

A

double stranded circular DNA supercoiled in a nucleoid

18
Q

how is DNA packed into eukaryotes?

A

wrapped around histones and coiled into chromatin then into chromosomes

19
Q

what 2 nucleotides are purines?

A

adenine and guanine

20
Q

what 2 nucleotides are pyrimidines?

A

cytosine and thymine