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DIT RNA viruses Flashcards

1
Q

What are the double stranded RNA viruses?

A

Reovirus family. Nonenveloped

Rotavirus is main cause of fatal diarrhea in kids worldwide

Coltavirus is colorado tick fever virus

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2
Q

Clinical presentation of rotavirus?

A

Diarrhea and vomiitng.

United states during winter months in daycare centers/kindergartens

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3
Q

What is presentation of colorado tick fever?

A

Coltivirus (easy to remember COL COLorado and TI for Tick fever)

Flu like illness in western mountains that resolves without treatment.

Reovirus (dsDNA)

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4
Q

What kind of virus do you see with picornavirus?

What is unique about genome?

A

Genome is easy b/c picoRNAvirus (small RNA virus)

PERCH on a peak (pico)
Polio
Echovirus
Rhinovirus
Coxsackievirus
HAV

One large polypeptide that is cleaved by proteases into functional viral proteins

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5
Q

What diseases cause rash on palms and soles?

A

Coxsackie
Meningococcus
RMSF
Syphilis

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6
Q

What three diseases can be caused by coxsackie?

A

positive strand RNA picoRNAvirus

Hand foot and mouth
Pericarditis
myocarditis

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7
Q

What type of virus is norovirus?

what does it cause?

A

Puking and shitting

ssRNA+ sense calicivirusus

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8
Q

What are the flaviviruses?

A

Flavi means yellow, so think jaundice annnddd… Basically shit from mosquitos that fuck you up

\+ssRNA
HCV
Dengue
Yellow Fever
St luis encephalitis
West nile
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9
Q

What type of virus is yellow fever? What are symptoms?

A

flavivirus (means yellow)
+ssRNA

High fever, black puke (from blood), jaundice

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10
Q

Dengue fever is what virus? Symptoms?

A

See patient with serve muscle/joint pain, headache (retroorbital), hemorrhagic fever is possible.

Thrombocytopenia tested with tourniquet test (DIT page 299)

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11
Q

West nile causes what symptoms?

A

Headache, mailaise, myalgia and anorexia for 3-6 days then some get encephalitis and flaccid paralysis (like polio hitting the anterior horn)

possibly death

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12
Q

What type of virus is rubella?

A

Toga virus. ss+RNA

Maculopapular rash lymphadenopathy and arthralgia

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13
Q

Congenital rubella syndrome?

A

the R in TORCH (it is a toga virus fyi.)

Blind and Deaf blueberry with heart problems.

blueberry muffin
Cardiac defect (PDA, pulmonic stenosis)
DEAFNESS
Cataracts

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14
Q

What are the two retroviruses?

A

+ ssRNA

HIV and HTLV

has reverse transcriptase

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15
Q

What are two virulence factors of influenza? what type of virus?

A

Othomyxovirus

Hemagglutinin promotes viral attachment to host cell

Neuraminidase helps release progeny virions

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16
Q

What is most fatal aspect of influenza?

A

secondary bacterial infections: Strep pneumo and staph a

17
Q

What is genetic shift?

A

segmented genomes traded in cells that are coinfected by different types of influenza and causes pandemics

It is genetic reassortment

18
Q

What is mechanism of zanamivir and oseltamivir?

A

Neuraminidase inhibitors: block release of virus.

Influenza A and B (o is oral)

Must be used early in illness to matter

19
Q

What causes croup?

A

Parainfluenza virus: Paramyoxivirus (-ssRNA)

20
Q

What is the protein in RSV that causes cells to clump?

What drug targets it?

A

Syncytia is caused by F fusion protein

Palivizumab is the target for it to treat RSV in premature babies

21
Q

Mechanism of ribavirin?

Use?

A

Guanosine analog

RSV and Hep C (ribavirin on interferon alpha used for hep C)

Hemolytic anemia

22
Q

Measles symptoms? type of virus?

A

Paramyxovirus (rubeola)

3 C’s of measles
Cough
Coryza (runny nose)
Conjunctivitis

descending rash and koplik spots (bright red spots on buccal mucosa)

23
Q

What are koplik spots?

A

Red spots on buccal mucosa that precede the measles rash

24
Q

Rash of measles?

A

Starts on head and moves down the body

25
Q

Measles complications?

A

Fetal loss
Premature delivery
Encephalitis: can be years later

26
Q

Roseola vs rubeola?

A

Roseola is HHV-6 with high fever then diffuse rash

Rubeola is measles with koplik spots then descending rash and three c’s

27
Q

Mumps is what type of virus?

Symptosm?

A

Paramyxovirus

POM-pom testes

Parotitis
Orchitis (leading to sterility possibly)
Meningitis

28
Q

Rabies is what kind of virus?

A

Rhabdovirus (R for Rabies and RNA)

29
Q

Capsid of rabies?

A

Bullet shaped, b/c old yeller had rabies, and a bullet killed him

30
Q

What are negri bodies?

A

eosinophilic inclusions often in purkinje cells with rabies

31
Q

What does hantavirus cause?

How is it spread? know that

A

hemorrhagic fever

progressive pulm edema and resp failure

spread by mouse urine

32
Q

Aseptic meningitis?

A

Enteroviruses (echovirus and coxsackievirus), and mumps

Boards DIT (43 decks)

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