DIT antiarrythmics

Question 1

What are the anti arrhythmic classes? Mnemonic

Answer 1

No Boy Keeps Clean

Na blockers I
Beta lockers II
K+ blocker III
Calcium channel is IV

Question 2

Class Ia?
Class Ib?
Class Ic?

Answer 2

Na blockers (slow depolarization of myocytes)

Double Quarter Pounder
Disopyramide Quinidine, Procainamide

Lettuce Mayo Tomato
Lidocaine, Mexilitine, tocainade

Fries Please
Flecainaide, Prpafenone

Question 3

What does 1a affect?

Answer 3

Slow depolarization, LONGER Effective refractory (longer QT)

Question 4

What is used for WPW? What is symptom?

Answer 4

Procainamide (only time you use it)

SLE symptom (Procainamide in SHIPP mnemonic)

Question 5

Side effects of quinidine?

Answer 5

Cinchonism (headache, dizziness, tinnitus), thrombocytopenia, torsades (longer QT)

Question 6

Lidocaine use?

Answer 6

Acute ventricular tachyarrhythmia, digitalis, MOST MI

IB is Best post MI

Question 7

What do you use post MI?

Answer 7

IB is Best post MI (B)

Question 8

When is IC contraindicated?

Answer 8

isChemic disease IC is ContraindiCated.

Only used as a last resort in VT

Question 9

How does a beta blocker help with arrhythmia?

Answer 9

Prolongs frequency of phase 4 in sinus.

Question 10

Tx for overdose with beta blocker?

Answer 10

Glucagon (it activates things shut down by it, more cAMP)

Question 11

What phase does class III work on?

Answer 11

Phase III. Slow down slow voltage gated potassium channel

Question 12

Drugs of class III?

Answer 12

Sotolol and amiodarone, ibutilide, dofetilide (notice the first two are most common)

Question 13

Amiodarone toxicity?

Answer 13

Check your:
PFTs: pulmonary fibrosis
LFTs: hepatotoxicity
TFTs: hyper or hypothyroidism (b/c a ton of IODINE in amIODaroNE)
Photodermatitis (SAT mnemonic with sulfonamides and tetracycline)
Neuro, constipation, VC…
corneal deposits

Pulmonary function test
liver function test
thyroid function test

Question 14

Clacium channel blockers are what drugs?

Answer 14

Verapamil and ditiazem

Question 15

What do IV drugs do?

Answer 15

Decrease conduction through AV b/c slows rise of action potential

Question 16

Dihydropyridine vs non-dihydropyridine?

Answer 16

Dihydropyridine is for vessels and ends in dipine (DIhydroPiridINE)

Nondihydropyridine is in heart and has non of those letters

Question 17

Symptos of IV?

Answer 17

well they may have unintentional effects in periphery: flushing and edema.

Also constipation, CHF of course with the effect of drug, AV block, yeah sinus node depression, yeah

Question 18

Adenosine mechanism?

Answer 18

Increases K+ leaving cell, so hyper polarizes the cell, so everything restarts as it drops down. But then metabolized fast, and it works again

Question 19

Adensoine use?

Answer 19

SVT Dx and Tx

Question 20

What is adenosine blocked by?

Answer 20

Theophylline (asthmatic or COPD patients)

Question 21

Magnesium use?

Answer 21

torsades