DIT Brain Tumors Flashcards
How is prognosis of glioblastoma?
Terriple 6 months to a year (Ted Kennedy had one)
Where are glioblastomas?
Cerebral hemisphere.
Describe a glioblastoma grossly:
Irregular masses with necrotic centers. Surroudned by edema
How do you stain glioblastoma?
GFAP is taken up by astrocytes. You see psuedopalisading pattern. The tumors have snake like arrangement of tumor after stain
What are the 4 most common kind of brian tumors in adults in order?
MGM studios. Easy to remember.
Mets
Glioblastoma (bad)
Meningioma (not as bad)
Schwannoma
Describe location and growth rate of meningioma?
Slowly growing and in arachnoid cells near surface of brain.
SO OFTEN RESECTABLE
What brain tumor has psammoma bodies?
Meningioma (calcifications and look like rings)
What brian tumor has whorled bodies on histology?
Meningioma. Circular whorled
Schwannoma are associated with what type of nerve?
CN VIII. They are swhannomas. Cause tinnitus, hearing loss.
What is tumor marker for schwannoma?
S-100
When do you see bilateral schwannomas?
Neurofibromatosis type 2 (chromasome 22, b/c 2)
Oligodendroglioma looks like what on histology?
Fried egg appearance. Clearing of cytoplasm (we learned that before).
Oligo my eggo!
You see this in seminomas and also in koilocytes in HPV.
Where do you find oligodendroglioma?
Frontal lobes.
Pituitary adenoma secretes all sorts of stuff. What is most common secretion?
Prolactin. Other kinds of acromegaly. Compresses optic chasm to cause bitemporal hemianopsia
What is hemangioblastoma associated with?
von Hippel-Lindau syndrome. (chromasome 3)
What does von Hippel-Lindau cause?
Hemangioblastoma
Renal cell carcinoma
Chromosome 3 b/c 3 words
What brain tumor can cause secondary polycythemia?
Hemangioblastoma (cerebellar tumor)
how do you remember 3 most common pediatric tumors?
kids like theme parks
Animal kingdom, magic kingdom, epcot
Astrocytoma
Medulloblastoma
Ependymoma
Where are adult brain tumors? where are pediatric brain tumors?
Supratentorial (adults are taller)
Infratentorial (kids are shorter)
Where are pilocytic astrocytoma?
Posterior fossa
What is the marker for pilocytic astrocytoma?
GFAP of course (astrocytes take it up b/c they are glial cells)
What is a rosenthal fiber?
Eosinophilic corkscrew fibers that are very pink and pathomnemonic. Policy tic astrocytoma.
What is a medulloblastoma?
malignant cerebellar tumor in kids.
What is a problem that can happen in both medulloblastoma and ependymoma?
Compression of 4th ventricle in kids.
What brain tumor has homer right rosettes?
Medulloblastoma. The homer wright circles on histology. KNOW THAT!
What has perivascular psuedorossete?
Ependymoma. Cells around a blood vessel. KNOW THAT
What is a craniopharyngioma?
Tumor from rathke’s pouch. Benign. Compresses optic chasm.
Unique b/c supratentorial.
