DIT Brain Tumors Flashcards
How is prognosis of glioblastoma?
Terriple 6 months to a year (Ted Kennedy had one)
Where are glioblastomas?
Cerebral hemisphere.
Describe a glioblastoma grossly:
Irregular masses with necrotic centers. Surroudned by edema
How do you stain glioblastoma?
GFAP is taken up by astrocytes. You see psuedopalisading pattern. The tumors have snake like arrangement of tumor after stain
What are the 4 most common kind of brian tumors in adults in order?
MGM studios. Easy to remember.
Mets
Glioblastoma (bad)
Meningioma (not as bad)
Schwannoma
Describe location and growth rate of meningioma?
Slowly growing and in arachnoid cells near surface of brain.
SO OFTEN RESECTABLE
What brain tumor has psammoma bodies?
Meningioma (calcifications and look like rings)
What brian tumor has whorled bodies on histology?
Meningioma. Circular whorled
Schwannoma are associated with what type of nerve?
CN VIII. They are swhannomas. Cause tinnitus, hearing loss.
What is tumor marker for schwannoma?
S-100
When do you see bilateral schwannomas?
Neurofibromatosis type 2 (chromasome 22, b/c 2)
Oligodendroglioma looks like what on histology?
Fried egg appearance. Clearing of cytoplasm (we learned that before).
Oligo my eggo!
You see this in seminomas and also in koilocytes in HPV.
Where do you find oligodendroglioma?
Frontal lobes.
Pituitary adenoma secretes all sorts of stuff. What is most common secretion?
Prolactin. Other kinds of acromegaly. Compresses optic chasm to cause bitemporal hemianopsia
What is hemangioblastoma associated with?
von Hippel-Lindau syndrome. (chromasome 3)