DIT Brain Tumors Flashcards

1
Q

How is prognosis of glioblastoma?

A

Terriple 6 months to a year (Ted Kennedy had one)

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2
Q

Where are glioblastomas?

A

Cerebral hemisphere.

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3
Q

Describe a glioblastoma grossly:

A

Irregular masses with necrotic centers. Surroudned by edema

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4
Q

How do you stain glioblastoma?

A

GFAP is taken up by astrocytes. You see psuedopalisading pattern. The tumors have snake like arrangement of tumor after stain

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5
Q

What are the 4 most common kind of brian tumors in adults in order?

A

MGM studios. Easy to remember.

Mets
Glioblastoma (bad)
Meningioma (not as bad)
Schwannoma

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6
Q

Describe location and growth rate of meningioma?

A

Slowly growing and in arachnoid cells near surface of brain.

SO OFTEN RESECTABLE

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7
Q

What brain tumor has psammoma bodies?

A

Meningioma (calcifications and look like rings)

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8
Q

What brian tumor has whorled bodies on histology?

A

Meningioma. Circular whorled

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9
Q

Schwannoma are associated with what type of nerve?

A

CN VIII. They are swhannomas. Cause tinnitus, hearing loss.

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10
Q

What is tumor marker for schwannoma?

A

S-100

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11
Q

When do you see bilateral schwannomas?

A

Neurofibromatosis type 2 (chromasome 22, b/c 2)

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12
Q

Oligodendroglioma looks like what on histology?

A

Fried egg appearance. Clearing of cytoplasm (we learned that before).

Oligo my eggo!

You see this in seminomas and also in koilocytes in HPV.

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13
Q

Where do you find oligodendroglioma?

A

Frontal lobes.

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14
Q

Pituitary adenoma secretes all sorts of stuff. What is most common secretion?

A

Prolactin. Other kinds of acromegaly. Compresses optic chasm to cause bitemporal hemianopsia

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15
Q

What is hemangioblastoma associated with?

A

von Hippel-Lindau syndrome. (chromasome 3)

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16
Q

What does von Hippel-Lindau cause?

A

Hemangioblastoma
Renal cell carcinoma

Chromosome 3 b/c 3 words

17
Q

What brain tumor can cause secondary polycythemia?

A

Hemangioblastoma (cerebellar tumor)

18
Q

how do you remember 3 most common pediatric tumors?

A

kids like theme parks

Animal kingdom, magic kingdom, epcot

Astrocytoma
Medulloblastoma
Ependymoma

19
Q

Where are adult brain tumors? where are pediatric brain tumors?

A

Supratentorial (adults are taller)

Infratentorial (kids are shorter)

20
Q

Where are pilocytic astrocytoma?

A

Posterior fossa

21
Q

What is the marker for pilocytic astrocytoma?

A

GFAP of course (astrocytes take it up b/c they are glial cells)

22
Q

What is a rosenthal fiber?

A

Eosinophilic corkscrew fibers that are very pink and pathomnemonic. Policy tic astrocytoma.

23
Q

What is a medulloblastoma?

A

malignant cerebellar tumor in kids.

24
Q

What is a problem that can happen in both medulloblastoma and ependymoma?

A

Compression of 4th ventricle in kids.

25
Q

What brain tumor has homer right rosettes?

A

Medulloblastoma. The homer wright circles on histology. KNOW THAT!

26
Q

What has perivascular psuedorossete?

A

Ependymoma. Cells around a blood vessel. KNOW THAT

27
Q

What is a craniopharyngioma?

A

Tumor from rathke’s pouch. Benign. Compresses optic chasm.

Unique b/c supratentorial.