DIT Antidotes Flashcards
Methamphetamine antidote
Ammonium Chloride to acidify urine to get rid of drug
Methamphetamine tx
benzo, antipsychotics, antihypertensives
Acetaminophen antidote
N-acetylcystine (replenish glutathione)
NAPQI would kill hepatocytes, and glutathione will conjugate it to make not poisonous
Aspirin overdose antidote
Sodium bicarb/dialysis
Organophosphate OD tx?
pralidoxime (reactivate cholinesterase)
Atropine
Antimuscarinic tx?
Physostigmine
Beta blockers/Verapamil OD tx? (3 things)
Bradycardia: Glucagon (increases cAMP in myocardium)
Atropine takes away brakes
Calcium contractility increaed
Digitalis OD tx?
arrythmia is danger so you make sure potassium and magnesium are ok
If severe OD: Anti-Dig fragments
Supportive care usually works fine
Ate a bottle of vitamins, hematemesis, melana and lethargy tx?
Iron poisoning! (can happen with lots of transfusions)
DeFERoxamine, deFERasirox (easy to remember) which is chelating agent
Lead poisoning: child developmental delay, GI symptoms. How do you tx? 4 things
Dimercaprol
EDTA
Succorer
Penicillamine
Mercury, arsenic or gold?
Dimercaprol, succimer
Think of dime for monetary unit for gold, or merca for mercury
Copper, arsenic or gold?
Penicillamine (copper pennies)
Wilson’s disease
Cyanide toxicity (house fired, sodium nitroprusside)
Nitrites, hydroxocobalamine
Methemoglobin? blood is brown
Methylene blue, vit c
Carbon monoxide poisoning (lamps, heaters, stove…)
Hyperberic O2
Methanol or ethylene glycol?
Fomepizole
Alcohol is other option if not available
Opioid OD?
Naloxone/naltrexone
Benzo OD?
Flumazenil (remember Ben likes if fast? Flumazenil is Florence telling Ben no!)
TCAs OD?
Sodium bicarb (its acidic)
Heparin OD?
Protamine (H in heparin is like a proton, and Protamine is tx!)
Warfarin?
Vitamin K (takes days)
FFP needed for acute Tx
tPA, streptokinase, urokinase tx?
Aminocaproic acid
Theophylline tachycardia, arrythmia OD tx?
Beta blocker
