DIT Antidotes

Question 1

Methamphetamine antidote

Answer 1

Ammonium Chloride to acidify urine to get rid of drug

Question 2

Methamphetamine tx

Answer 2

benzo, antipsychotics, antihypertensives

Question 3

Acetaminophen antidote

Answer 3

N-acetylcystine (replenish glutathione)

NAPQI would kill hepatocytes, and glutathione will conjugate it to make not poisonous

Question 4

Aspirin overdose antidote

Answer 4

Sodium bicarb/dialysis

Question 5

Organophosphate OD tx?

Answer 5

pralidoxime (reactivate cholinesterase)

Atropine

Question 6

Antimuscarinic tx?

Answer 6

Physostigmine

Question 7

Beta blockers/Verapamil OD tx? (3 things)

Answer 7

Bradycardia: Glucagon (increases cAMP in myocardium)

Atropine takes away brakes

Calcium contractility increaed

Question 8

Digitalis OD tx?

Answer 8

arrythmia is danger so you make sure potassium and magnesium are ok

If severe OD: Anti-Dig fragments

Supportive care usually works fine

Question 9

Ate a bottle of vitamins, hematemesis, melana and lethargy tx?

Answer 9

Iron poisoning! (can happen with lots of transfusions)

DeFERoxamine, deFERasirox (easy to remember) which is chelating agent

Question 10

Lead poisoning: child developmental delay, GI symptoms. How do you tx? 4 things

Answer 10

Dimercaprol
EDTA
Succorer
Penicillamine

Question 11

Mercury, arsenic or gold?

Answer 11

Dimercaprol, succimer

Think of dime for monetary unit for gold, or merca for mercury

Question 12

Copper, arsenic or gold?

Answer 12

Penicillamine (copper pennies)

Wilson’s disease

Question 13

Cyanide toxicity (house fired, sodium nitroprusside)

Answer 13

Nitrites, hydroxocobalamine

Question 14

Methemoglobin? blood is brown

Answer 14

Methylene blue, vit c

Question 15

Carbon monoxide poisoning (lamps, heaters, stove…)

Answer 15

Hyperberic O2

Question 16

Methanol or ethylene glycol?

Answer 16

Fomepizole

Alcohol is other option if not available

Question 17

Opioid OD?

Answer 17

Naloxone/naltrexone

Question 18

Benzo OD?

Answer 18

Flumazenil (remember Ben likes if fast? Flumazenil is Florence telling Ben no!)

Question 19

TCAs OD?

Answer 19

Sodium bicarb (its acidic)

Question 20

Heparin OD?

Answer 20

Protamine (H in heparin is like a proton, and Protamine is tx!)

Question 21

Warfarin?

Answer 21

Vitamin K (takes days)

FFP needed for acute Tx

Question 22

tPA, streptokinase, urokinase tx?

Answer 22

Aminocaproic acid

Question 23

Theophylline tachycardia, arrythmia OD tx?

Answer 23

Beta blocker