Cutaneous Manifestations of Systemic Disease Flashcards
what condition is a result of plasma cell dyscrasia producing monoclonal light chains that deposit in multiple organ systems
- AL amyloidosis
cutaneous findings of this condition include macroglossia (large tongue), pinch purpura, waxy thickening, and infiltrated nodules and plaques in the periorbital region
- AL amyloidosis
in AL amyloidosis, what can serum and urine protein electrophoresis detect
- circulating light chains
diagnosis of AL amyloidosis requires
- biopsy of affected organ - apple green birefringence
treatment of AL amyloidosis
- treat plasma cell dyscrasia
what causes pinch purpura in AL amyloid
- capillary fragility due to mild trauma
what causes trauma on the lateral tongue in AL amyloid
- macroglossia
what is a systemic inflammatory disease characterized by hyperactivity of cell-mediated immunity that generally affects the lungs and is predisposed to African Americans and females
- systemic sarcoidosis
what does biopsy of systemic sarcoidosis show
- non-caseating granulomas
what does systemic sarcoidosis present with on the skin
- symmetric red-brown papules and plaques
what condition is sarcoidosis with erythema nodosum, hilar adenopathy, fever, migrating poly arthritis, and acute iritis
- Lofgren’s syndrome
what is the prognosis of Lofgren’s syndrome
- good prognosis
systemic sarcoid has a predilection for what spots on the body
- scars and tattoos
is there a cure for systemic sarcoid
- no
how to help control systemic sarcoid
- corticosteroids - antimalarials - minocycline - immunomodulators
what is a necrotizing skin condition associated with diabetes
- necrobiosis lipoidica
necrobiosis lipoidica is possibly a _______ or ______ disorder
- microangiopathy - collagen disorder
what condition is characterized by yellow-brown atrophic, telangiectatic plaques with an elevated violaceous rim which is usually pretibial
- necrobiosis lipoidica
how the lesions in necrobiosis lipoidica feel
- may be painful - or decreased sensation
treatment of necrobiosis lipoidica
- topical steroids
what condition presents with fever, malase with abrupt onset of erythematous plaques with occasional vesiculation
- sweet’s syndrome
average age of onset of sweet’s syndrome
- 30-60s
triggers of sweet’s syndrome
- URI streptococcal infections
- malignancies (AML)
- chronic inflammatory disorders
treatment of sweet’s syndrome
- treat underlying condition
- systemic corticosteroids
what is the most common form of panniculitis which presents with tender nodules on the anterior lower legs without ulceration
- erythema nodosum
causes of erythema nodosum
- recent streptococcal infection - antibiotics - oral contraceptives - pregnancy - chronic inflammatory diseases
what gender does erythema nodosum classically present
in age
- women - 2nd-3rd decades of life
treatment of erythema nodosum
- NSAIDS - treat underlying systemic disease
what condition is associated with end stage renal disease and starts with painful, violaceous, subcutaneous nodules and plaques
- calcific uremic arteriolopathy (calciphylaxis)
where does calcific uremic arteriolopathy typically form
- lower extremities - trunk
biopsy of calcific uremic arteriolopathy demonstrates
- arteriolar calcification
treatment of calcific uremic arteriolopathy
- surgical debridement - kidney transplant - stop vitamin D, calcium, warfarin meds
