Actinic Keratosis, Squamous Cell Carcinoma, Basal Cell Carcinoma Flashcards
what is an erythematous nodule that increases in size and can be itchy and bleed after minor traumas. generally associated with a history of extensive sun exposure as a teen.
- squamous cell carcinoma
SCC is most commonly in patients with ______ skin in sun-exposed sites
- white/fair
SCC has ______ mortality compared to basal cell carcinoma
- increased
cell of origin for SCC
- keratinocyte
mutations for SCC
- p53 UV induced
what condition may also present as a cutaneous horn
- SCC
what is the condition where keratinocyte atypia is confined to the epidermis and does not invade past the dermal-epidermal junction
- Bowen’s disease (SCC in situ)
if SCC atypia involves the dermis then it becomes ______ SCC
- invasive
treatment for invasive SCC
- surgical excision
treatment for in situ SCC
- curette and dessication
nonsurgical treatment for SCC
- 5-fluorouracil - imiquimod - radiation
higher metastatic tumors for SCC are on what areas of the body
- scalp - ears - nose - lips
a patient with a previous skin cancer that presents with rough, scaly, thin, red-pink plaques scattered on the forehead and right temple area could have what condition
- actinic keratoses
AKs are (premalignant, malignant, or benign)
- premalignant
mutation for AKs
- UV mutation in p53
what are gritty erythematous macules or thin plaques on sun-exposed surfaces
- actinic keratosis
if AKs are thick, tender or >6mm, there is a higher suspicion of _____
- SCC
what results from UV damage and is present on sun-exposed areas with one or many small brown macules
- solar lentigo
what presents with a red neck with rhomboidal furrows
- cutis rhomboidalis nuchae
what present with degenerated elastin, fine modularity, and a pebbly surface
- solar elastosis
what presents with extravasated erythrocytes and increased perivascular inflammation with easy bruising
- actinic purpura
what represents AKs on the lips, and is most often on fit lower lip
- actinic cheilosis
treatment of AKs for localized therapies
- cryotherapy
treatment of AKs for field therapies
- 5-Fluorouracil creams - imiquimod creams
what presents as a pearly pink papule with telangiectasis
- basal cell carcinoma
what is the most common skin cancer
- basal cell carcinoma
basal cell carcinoma arises from what cell
- keratinocytes
what mutation is there in basal cell carcinoma
- PTCH (tumor suppressor gene) mutation
what subtype of BCC is the most common subtype that presents as a pearly papule or nodule with rolled border and telangiectasies and that is frequently found on the head and neck
- nodular BCC
what subtype of BCC presents with features suggestive of BCC including a pink or translucent color, telangiectasia, slightly rolled border, with a patch or plaque
- superficial BCC
other subtypes of BCC
- ulceration - pigmentation - morpheaform (scar-like)
treatment of BCC
- curette and desiccation - cryotherapy
treatment of superficial BCC
- imiquimod cream - 5-fluorouracil cream
what offers superior histologic analysis of tumor margins and maximal conservation of tissue
- Mohs surgery
recurrence rates are lower with ____ compared to other modalities
- Mohs
what surgical treatment includes tumors that are large, recurrent, or have indistinct border
- Mohs
indurated erythematous lesions with keratin are _____ until proven otherwise
- SCC
