Actinic Keratosis, Squamous Cell Carcinoma, Basal Cell Carcinoma

Question 1

what is an erythematous nodule that increases in size and can be itchy and bleed after minor traumas. generally associated with a history of extensive sun exposure as a teen.

Answer 1

• squamous cell carcinoma

Question 2

SCC is most commonly in patients with ______ skin in sun-exposed sites

Answer 2

• white/fair

Question 3

SCC has ______ mortality compared to basal cell carcinoma

Answer 3

• increased

Question 4

cell of origin for SCC

Answer 4

• keratinocyte

Question 5

mutations for SCC

Answer 5

• p53 UV induced

Question 6

what condition may also present as a cutaneous horn

Answer 6

• SCC

Question 7

what is the condition where keratinocyte atypia is confined to the epidermis and does not invade past the dermal-epidermal junction

Answer 7

• Bowen’s disease (SCC in situ)

Question 8

if SCC atypia involves the dermis then it becomes ______ SCC

Answer 8

• invasive

Question 9

treatment for invasive SCC

Answer 9

• surgical excision

Question 10

treatment for in situ SCC

Answer 10

• curette and dessication

Question 11

nonsurgical treatment for SCC

Answer 11

• 5-fluorouracil - imiquimod - radiation

Question 12

higher metastatic tumors for SCC are on what areas of the body

Answer 12

• scalp - ears - nose - lips

Question 13

a patient with a previous skin cancer that presents with rough, scaly, thin, red-pink plaques scattered on the forehead and right temple area could have what condition

Answer 13

• actinic keratoses

Question 14

AKs are (premalignant, malignant, or benign)

Answer 14

• premalignant

Question 15

mutation for AKs

Answer 15

• UV mutation in p53

Question 16

what are gritty erythematous macules or thin plaques on sun-exposed surfaces

Answer 16

• actinic keratosis

Question 17

if AKs are thick, tender or >6mm, there is a higher suspicion of _____

Answer 17

• SCC

Question 18

what results from UV damage and is present on sun-exposed areas with one or many small brown macules

Answer 18

• solar lentigo

Question 19

what presents with a red neck with rhomboidal furrows

Answer 19

• cutis rhomboidalis nuchae

Question 20

what present with degenerated elastin, fine modularity, and a pebbly surface

Answer 20

• solar elastosis

Question 21

what presents with extravasated erythrocytes and increased perivascular inflammation with easy bruising

Answer 21

• actinic purpura

Question 22

what represents AKs on the lips, and is most often on fit lower lip

Answer 22

• actinic cheilosis

Question 23

treatment of AKs for localized therapies

Answer 23

• cryotherapy

Question 24

treatment of AKs for field therapies

Answer 24

• 5-Fluorouracil creams - imiquimod creams

Question 25

what presents as a pearly pink papule with telangiectasis

Answer 25

• basal cell carcinoma

Question 26

what is the most common skin cancer

Answer 26

• basal cell carcinoma

Question 27

basal cell carcinoma arises from what cell

Answer 27

• keratinocytes

Question 28

what mutation is there in basal cell carcinoma

Answer 28

• PTCH (tumor suppressor gene) mutation

Question 29

what subtype of BCC is the most common subtype that presents as a pearly papule or nodule with rolled border and telangiectasies and that is frequently found on the head and neck

Answer 29

• nodular BCC

Question 30

what subtype of BCC presents with features suggestive of BCC including a pink or translucent color, telangiectasia, slightly rolled border, with a patch or plaque

Answer 30

• superficial BCC

Question 31

other subtypes of BCC

Answer 31

• ulceration - pigmentation - morpheaform (scar-like)

Question 32

treatment of BCC

Answer 32

• curette and desiccation - cryotherapy

Question 33

treatment of superficial BCC

Answer 33

• imiquimod cream - 5-fluorouracil cream

Question 34

what offers superior histologic analysis of tumor margins and maximal conservation of tissue

Answer 34

• Mohs surgery

Question 35

recurrence rates are lower with ____ compared to other modalities

Answer 35

• Mohs

Question 36

what surgical treatment includes tumors that are large, recurrent, or have indistinct border

Answer 36

• Mohs

Question 37

indurated erythematous lesions with keratin are _____ until proven otherwise

Answer 37

• SCC