Critical appraisal Flashcards

1
Q

what is critical appraisal used for

A

make clinically informed decisions

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2
Q

describe the transdisciplinary model of EBM

A

best research evidence
population - does it work in adolescents etc
environmental and organisational context - lab texts and finance
resources available

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3
Q

to determine if the content is appropriate you need to look at:

A

exposure eg salt on Bp
outcome
population eg middle age men huge effect, older generations less - how define middle age
study design, sampling and methods eg biomarkers are more accurate - use papers with more accurate research
whether the results help you answer the qn - can you interpret them, what did I already know

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4
Q

defining a critical appraisal

A

process of systematically examining research evidence to assess its validity, results and relevance before using it to inform a decision
close gaps between research and practice

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5
Q

how do you start a critical appraisal

A

ask focussed questions - break it down, papers are most likely going to answer the question
find the evidence
critically appraise it
include information on randomisation - if not there, does it impact results

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6
Q

what is the problem with redrafts of articles

A

more possible for errors

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7
Q

what should a good scientific method include

A

systematic research process
logical - induction/deduction
empirical - evidence based
reductive - generalisation, apply research to other environments, association
replicable - methodology
deductive - qualitative then empirically test it - have information and then look for pattern
inductive - have theory then find information

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8
Q

what is basic research

A

questions at cellular level
see if there is an effect
more difficult and controlled than applied research

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9
Q

what is applied research

A

accept basic research
look what happens in a clinical environment
confounding involved

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10
Q

describe the research process

A

review literature available - need to know what is common knowledge
formulate qn - recognise the need for new information
select appropriate research design - find the evidence - wrong evidence=wrong ans
collect relevant data
interpret findings - appraisal - evaluate validity and usefulness of details
publish findings
repeat - act on evidence - what going to do with new findings
evaluation and reflection - did the changes have the desired effect, look at clinical knowledge

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11
Q

why is critical appraisal important

A

put new information into practice
keep up to date - what is the best treatment
patients can’t look beyond initial research so are not fully informed

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12
Q

what are the responsibilities of scientists

A

need to publish nil results
timely - inform other people’s practice
conduct work with honesty and integrity
ensure results and methods conducted in timely orderly and open fashion

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13
Q

research evidence

A

need to control everything that affects exposure
have solid question, structure search comprehensively, keep good notes
have questions that you want the papers you find to answer

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14
Q

approaching a critical review

A

find models - guided by others
problem formulation - which topic is under consideration and what are the constituent issues, have theory and biological understanding behind the theory
literature reviews
evaluation of findings - against your criteria
analysis and interpretation of literature
critical and evaluative account - not description
describe and analyse existing data and what has been added
recall similarities and differences, consistancies
explain reasons for these - from biological understanding
merge papers and see what learnt overall

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15
Q

Hierarchy of study designs

A

cohort study - see if treatment has improved over time, more confidence in results

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16
Q

ideal design for outcome

A

look at diagnostics - use cross sectional study - how many people with mammograms were sent to biopsy
prognosis - longitudinal cohort study - follow people though
therapeutic methods - RCT
screening - cross-sectional study
causation - cohort/case control study

17
Q

use of review checklists

A

different ideas what to present in paper
eg randomised control trial use CONSORT checklist
what authors what to write, why need to share info, and if they don’t what affects that has
obs studies: cohort, case-control and cross section - STROBE
what done, what they found, how we can learn from that

18
Q

what does a review that is done well do

A

help decide decision making, highlight good practice
learn from peoples mistakes
gaps in literature

19
Q

important notes

A
understand checklist 
what did and why 
do they know what else was in research 
are all the results included 
does conclusion help you ans your question 
is bias controlled for 
is study blinded 
were appropriate statistics applied
20
Q

checklist for a critical appraisal

A
Summarise the paper first: with a sentence for each of the following:
Why did they do it?
What did they do?
What did they find?
What did they conclude?
Then consider the following:
Question
Design
Population
Methods
Analysis
Confounding
Bias
Ethics
Interpretation