Connective tissue dsorders

Question 1

hypersensitivity in SLE

Answer 1

T3 hypersensitivity

Question 2

Ab in SLE

Answer 2

95% = ANA
anti-ds-DNA
Anti-SM Ab

Question 3

associations of SLE

Answer 3

inc in classical complement def
F>M
inc in afroC
can be drug induced

Question 4

ab in drug induced SLE

Answer 4

anti-histone ab

Question 5

sympto of SLE

Answer 5

SOAP BRAIN MD
Serositis, Oral ulcers, Arthritis, Photosensetivity, Blood Abn (AIHA, ITP, leukopenia), Renal Inv, ANA +ve, Immuno ft (anti dsDNA/Anti-SM), neuro sympto, malar rash, discoid rash

Question 6

sympto of limited sclerosis

Answer 6

= CREST - calcinosis, raynauds, esophageal dysmotility, sclerodactyly, telengiectasia
skin changes on face and distal to elbow/knee
asso with pulmo HTN
inc collagen in skin/org

Question 7

sympto of diffuse sclerosis

Answer 7

inflam in and arround muscle fibres, skin changes can occur anywhere , widespread organ involvement
asso with pulmo fib

Question 8

ab in diffuse sclerosis

Answer 8

anti Scl-70

Question 9

antibody in polymyositis/dermatomyositis

Answer 9

Anti-Jo-1 ab

Question 10

sympto of polymyositis/dermatomyositis

Answer 10

proximal muscle weakness, inc Ck and abn EMG