Breast pathology Flashcards

1
Q

what is duct ectasia

A

benign inflam and dilation of large breast ducts

no risk of malig

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2
Q

how does duct ectasia present

A

nipple discharge, pain, mass, nipple retraction

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3
Q

what is the main risk factor for duct ectasia

A

smoking

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4
Q

what is the nature of the discharge in duct ectasia

A

proteinaceous material and inflam cells, foamy macrophages

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5
Q

what is acute mastitis

A

acute inflam of breast due to inf (mainly staph)

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6
Q

who is acute mastitis seen in

A

lactating women - milk stasis + cracked skin

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7
Q

how does acute mastitis present

A

painful, red breast + fever

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8
Q

what is the treatment for acute mastitis

A

keep breasfeeding

drainage + abs

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9
Q

what is fat necrosis of the breast

A

inflam reaction to adipose tissue damage by trauma/radiothera/surg

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10
Q

how does fat necrosis of the breast present

A

painless breast mass in obese middle aged women, benign

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11
Q

what is breast fibrocystic diease

A

breast lumpiness due to normal response to hormones

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12
Q

how will a fibroadenoma present

A

circumscribed mobile breast lump in young women (20-30)

may evolve to phylodes tumour

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13
Q

how will phylodes tumour present

A

rapidly enlarging mass in >50y women

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14
Q

how will man intraductal papilloma present

A

bloody discharge due to benign papillary tumor arising in duct system

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15
Q

what is a radial scar

A

benign central scarring surrounded by proliferating glandular tissue

‘stellate mass’

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16
Q

how are ductal carcinomas in situ catagorised

A

by thewir risk of progression to an invasive breast carcinoma

17
Q

what is the treatment for a ductal carcinoma in situ

A

excision with clear margins

18
Q

what are the risk factors for invasive breast carcinomas

A

early menarche, late menopause, inc BMIU, COCP, BRCA, inc aclohol

19
Q

what is the screening program for inv breast carcinomas

A

every 3 y from 47-73 with mammogram

20
Q

what are the subtypes of invasive breast carcinomas

A

inv ductal - most common, big pleomorphic cells that move into stroma

Inv lobular - cells in single file chains

Tubular - well formed tubules with low grade nuclei

Mucinous - lots of extracellular mucin which goes into surrounding stroma

21
Q

what is an indicator of prognosis in invasive breast carcinomas

A

ER/PR response +ve = good prog

Her2 +ve = poor prog

22
Q

how will male breast cancer present

A

65y old with palpable lump, asso with BRCA 2 carriers