Congenital Heart And Other Defects Flashcards
Process of primitive heart tube formation
Cardiogenic mesoderm -> angiogenic cell clusters -> left and right endocardial tubes -> primitive heart tube
What is each endocardial tube continuous with
Dorsal aorta
Vitelloumbilical vein
What types of folding occurs in the primitive heart tubes
Cranial folding
Lateral folding
When does fusion of the 2 endocardial tubes to form the primitive heart tube finish
Day 21
What does the primitive myocardium form from
Mesoderm from foregut
When does the heart start to beat
Day 22
What causes the foramen ovale to close at birth
Left atrium pressure becomes higher than right atrium pressure
What does the heart septum form from
Septum primum
Septum secundum
How does the outflow tract of the heart partition
Neural crest forms bulbar ridges which grow and spiral
How many pairs of aortic arch arteries sprout from the aortic sac
5 (1-6 but 5 disappears)
What type of congenital heart defect is linked to migraines
Septal defects
Does a septal defect cause left right or right left shunting
Left right
How can septal defects be closed with
Fabric
Pericardium
Outflow tract defects
Persistent truncus arteriosus
Transposition of the great vessels
Tetralogy of fallot
Coarctation of aorta
Persistent truncus arteriosus
Pulmonary artery starts some distance above undivided truncus
What causes persistent truncus arteriosus
Truncoconal swellings fail to fuse
Transposition of the great vessels cause
Truncoconal septum straight instead of spiralled
Most common cyanotic heart defect
Transposition of great vessels
What causes tetralogy of fallot
Unequal separation of conus