Coccicioides immitis and posadasii Flashcards

1
Q

what is the key virulence factor for C. immitis and C. psadasii?

A

estrogen-binding proteins

-steroid hormones accelerate growth and maturation of spherules

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2
Q

what geographical area is predisposed to C. immitis?

A

American SW

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3
Q

what gender is more at risk for Coccidioides infx?

A

males

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4
Q

which group of females is at risk for coccidioides infx?

A

pregnant women, especially third trimester

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5
Q

what is the seasonality for coccidioides infx?

A

summer

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6
Q

what skin test will be positive in coccidioides patient, even if they are asymptomatic?

A

spherulin skin test

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7
Q

what are cutaneous manifestations of coccidioides?

A
maculopapular rash (esp. young patient)
erythema
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8
Q

what is the desert rheumatism triad?

A

fever/conjunctivitis
erythema
arthralgia

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9
Q

the presence of what thing in tissue sample micro exam is diagnostic for coccidioides?

A

presence of spherules

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10
Q

what lab tests are used to identify coccidioides infx?

A

IgM/IgG titers

spherulin DTH test (dissem. pts often neg)

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11
Q

what is the treatment for coccidioides infx?

A

amphotericin B lipid formulations

oral itraconazol

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12
Q

how is coccidioides prevented?

A

coccidioides infx cannot be prevented

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