Aspergillosis

Question 1

is Aspergillus a dimorphic fungi?

Answer 1

no

Question 2

what is the most common species of aspergillus that infects humans?

Answer 2

A. fumigatus

Question 3

what is the key cellular morphology feature of Aspergillus in its identification?

Answer 3

septate hyphae

-soldiers marching in a row

Question 4

what are risk factors for aspergillosis?

Answer 4

hyperimmunity to Aspergillus

severely immunocompromised

Question 5

Allergic bronchopulmonary aspergillosis (ABPA), Aspergilloma, and Invasive aspergillosis (IA) are caused by what type of growth in the body?

Answer 5

mycelial growth in the body

Question 6

what type of disease is Allergic Bronchopulmonary Aspergillosis (ABPA)?

Answer 6

hypersensitivity

Question 7

what type of infiltrates are seen on CXR of ABPA/Loeffler’s syndrome?

Answer 7

interstitial infiltrates

Question 8

what is a buzz word for ABPA/Loeffler’s syndrome?

Answer 8

urticaria

Question 9

what is seen in the sputum of ABPA/Loeffler’s syndrome patients?

Answer 9

eosinophilia

Charcot-Leyden crystals

Question 10

what is key in the CBC of ABPA/Loeffler’s syndrome?

Answer 10

peripheral eosinophilia

Question 11

what is the most significant diagnostic citerion of ABPA?

Answer 11

central bronchiectasis (sometimes "gloved finger"
asthma

Question 12

what are the fatal aspects of the pathogenesis of aspergilloma?

Answer 12

internal bleeding

hemoptysis

Question 13

what are the symptoms of aspergilloma?

Answer 13

hemoptysis

bronchiectasis

Question 14

what tests are used to detect aspergilloma?

Answer 14

CAT scan

bronchiscope

Question 15

what is the leading or common cause of death among most types of secondary immunocompromise?

Answer 15

invasive aspergillosis (IA)

Question 16

what differentiates IA from ABPA and aspergilloma?

Answer 16

hematogenous dissemination

Question 17

if a neutropenic patient presents with unremitting fever (that fails to respond to broad spectrum Abx) non-productive cough, what fungal disease could be causing it?

Answer 17

invasive aspergillosis (IA)

Question 18

what fungal disease is indicated by a “halo sign” on CT scan?

Answer 18

aspergillosis

Question 19

in a neutropenic patient, narrow, septate hyphae are observed on microscopy. what fungal agent could be responsible?

Answer 19

aspergillus

Question 20

what substance, found in serum testing, is indicative of what fungal agent?

Answer 20

aspergillus

Question 21

what is the treatment for aspergillosis?

Answer 21

voriconazole

amphotericin B

Question 22

how is aspergillosis prevented?

Answer 22

posaconazole