Aspergillosis Flashcards
is Aspergillus a dimorphic fungi?
no
what is the most common species of aspergillus that infects humans?
A. fumigatus
what is the key cellular morphology feature of Aspergillus in its identification?
septate hyphae
-soldiers marching in a row
what are risk factors for aspergillosis?
hyperimmunity to Aspergillus
severely immunocompromised
Allergic bronchopulmonary aspergillosis (ABPA), Aspergilloma, and Invasive aspergillosis (IA) are caused by what type of growth in the body?
mycelial growth in the body
what type of disease is Allergic Bronchopulmonary Aspergillosis (ABPA)?
hypersensitivity
what type of infiltrates are seen on CXR of ABPA/Loeffler’s syndrome?
interstitial infiltrates
what is a buzz word for ABPA/Loeffler’s syndrome?
urticaria
what is seen in the sputum of ABPA/Loeffler’s syndrome patients?
eosinophilia
Charcot-Leyden crystals
what is key in the CBC of ABPA/Loeffler’s syndrome?
peripheral eosinophilia
what is the most significant diagnostic citerion of ABPA?
central bronchiectasis (sometimes "gloved finger" asthma
what are the fatal aspects of the pathogenesis of aspergilloma?
internal bleeding
hemoptysis
what are the symptoms of aspergilloma?
hemoptysis
bronchiectasis
what tests are used to detect aspergilloma?
CAT scan
bronchiscope
what is the leading or common cause of death among most types of secondary immunocompromise?
invasive aspergillosis (IA)
what differentiates IA from ABPA and aspergilloma?
hematogenous dissemination
if a neutropenic patient presents with unremitting fever (that fails to respond to broad spectrum Abx) non-productive cough, what fungal disease could be causing it?
invasive aspergillosis (IA)
what fungal disease is indicated by a “halo sign” on CT scan?
aspergillosis
in a neutropenic patient, narrow, septate hyphae are observed on microscopy. what fungal agent could be responsible?
aspergillus
what substance, found in serum testing, is indicative of what fungal agent?
aspergillus
what is the treatment for aspergillosis?
voriconazole
amphotericin B
how is aspergillosis prevented?
posaconazole
