antifungal drugs

Question 1

what is the “gold standard” antifungal drug?

Answer 1

amphotericin B

Question 2

which drug interferes with DNA and RNA synthesis/function?

Answer 2

nucleoside analog:

5-Fluorocytosine (5-Fc)

Question 3

which drug inhibits fungal cell mitosis at metaphase by interaction with polymerized microtubules?

Answer 3

Mitosis inhibitor:

Griseofulvin

Question 4

which drugs inhibit cell wall synthesis by inhibiting synthesis of 1,3-B-D-glucan in fungal cell walls?

Answer 4

Echinocandins
Pneumocandins
Caspofungin

Question 5

which drug interacts with ergosterol, formation of aqueous channels, increased membrane permeability to univalent cations, and ultimately cell death?

Answer 5

Polyene antibiotics:

Amphotericin B lipid formulations

Question 6

which drugs cause ergosterol depletion and accumulation of aberrant and toxic sterols in the cell membrane?

Answer 6

imidazole/azoles:

ketoconazole
fluconazole
itraconazole
voriconazole

allulamines/thiocarbamates:

terbinafine

Question 7

which drug inhibits sterol reductase and isomerase?

Answer 7

morpholines