CMB1004/L29 Reproductive System Flashcards
What hormones are released by the testes?
Androgens (and oestrogens)
What hormones do ovaries secrete?
Oestrogens (and androgens)
Progesterone
Name the 2 types of gametogenesis.
Spermatogenesis
Oogenesis
Where do oocytes arrest?
Prophase of meiosis division 1 within primordial follicles
How many eggs are released by ovulation in a female’s lifetime?
500
Give the 3 phases of the ovarian cycle.
Phase 1 - follicular phase
Phase 2 - ovulation
Phase 3 - Luteal phase
How long does phase 1 of the ovarian cycle last?
Several months
Describe the pre-antral phase (in phase 1/follicular phase of ovarian cycle). (2)
Change of primordial follicle to primary follicle (zona pellucida formation)
Primary follicle matures into mature pre-antral follicle with thecal cell layer
What hormone limits the number of primary follicles developing at one time?
Antimullerian hormone
Describe the antral phase (in phase 1/follicular phase) of the ovarian cycle. (4)
Appearance of fluid filled atria
Increased layers of zona granulosa
Thicker zona pellucida
Theca interna more apparent
What is the growth of follicles dependent on?
Pituitary FSH
What is the role of theca cells?
Catalysis of androgen from cholestrol
What is the role of granulosa cells?
Contain aromatase to convert androgen to oestrogen
Describe the pre-ovulatory phase (in phase 1/follicular phase) of the ovarian cycle. (4)
Surge in LH causes arrest in metaphase of meiosis II
Haploid secondary oocyte and polar body forms
LH receptor and enzyme expression - progesterone production
Cytokines and hydrolytic enzymes released
What kind of event is ovulation?
Inflammatory