CMB1004/L02 Cell Membranes Flashcards

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1
Q

Name 2 common lipids in eukaryotes.

A

Phospholipids (mainly phosphoglycerides)
Cholestrol
Glycolipids

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2
Q

Name 3 of the 5 major phospholipids.

A

Phosphotidylethanolamine
Phosphotidylserine
Phosphotidylcholine
Sphingomyelin

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3
Q

Why does membrane fluidity need to be maintained?

A

Ensure cell survival

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4
Q

Give the 2 key parameters that influence membrane fluidity.

A

Lipid composition
Temperature

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5
Q

Give the 3 types of membrane-associated proteins.

A

Integral membrane proteins
Attached proteins
Peripheral, membrane-associated proteins

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6
Q

Give 3 functions of membrane proteins.

A

Transporters
Linkers
Receptors
Enzymes

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7
Q

What is the function of transporter membrane proteins?

A

To move nutrients, metabolites or ions across membranes

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8
Q

What is the function of membrane linker proteins?

A

To join membranes to intra- or extracellular macromolecules

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9
Q

What is the function of receptor proteins?

A

To transduce signals from the environment
To transport ligands

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10
Q

What is the glycocalix?

A

A cell coat which protects against chemical, physical and biological damage

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11
Q

Name 2 examples of glycoproteins.

A

N-glycans
O-glycans
Proteoglycans

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12
Q

Name 2 ways in which glycans affect health and disease.

A

Modulate inflammatory responses enabling viral immune escape
Promote cancer cell metastasis

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13
Q

Give 3 functions of the glycocalix.

A

Protection
Adhesion
Recognition
Storage

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14
Q

What is FRAP?

A

Fluorescent Recovery after Photobleaching

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15
Q

How do proteins move within the membrane?

A

Diffusion along membrane plane

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16
Q

What are membrane proteins restricted to?

A

Domains or membranes

17
Q

What traps agrin between neurones and muscles?

A

Basal lamina

18
Q

What does agrin do?

A

Initiates AchR clustering

19
Q

What maintains AchR clustering?

A

Rapsyn

20
Q

What is present in the intercellular space between T cells and APCs? (2)

A

T-cell receptors & CD2AP

21
Q

What is a result of alternative splicing in several positions along cDNA?

A

Multiple isoforms of agrin

22
Q

What is a B/z+ agrin isoform?

A

Agrin with a peptide insert in the -COOH terminal region

23
Q

What is a B/z0 agrin isoform?

A

Agrin without a peptide insert

24
Q

What makes up the majority of eukaryotic cytoskeletons?

A

Spectrin

25
Q

Give 3 examples of energy-driven transport.

A

Coupled transport
ATP driven transport
Light/redox driven transport

26
Q

Give 3 examples of membrane bending via proteins.

A

Vesicle budding
Cell movements
Cell division

27
Q

What 3 mechanisms mediate membrane curvature and stabilisation?

A

Nanoscopic curvature
Microscopic curvature
Macroscopic curvature

28
Q

What does nanoscopic composition involve? (2)

A

Lipid composition
Protein motif insertion

29
Q

What does microscopic composition involve? (1)

A

Protein scaffolding

30
Q

What does macroscopic composition involve? (1)

A

Cytoskeletal scaffolding

31
Q

Name 3 cellular processes requiring membrane deformation.

A

Organelle shaping
Protein sorting
Membrane scission
Membrane fusion
Enzyme activation