CMB1004/L02 Cell Membranes Flashcards
Name 2 common lipids in eukaryotes.
Phospholipids (mainly phosphoglycerides)
Cholestrol
Glycolipids
Name 3 of the 5 major phospholipids.
Phosphotidylethanolamine
Phosphotidylserine
Phosphotidylcholine
Sphingomyelin
Why does membrane fluidity need to be maintained?
Ensure cell survival
Give the 2 key parameters that influence membrane fluidity.
Lipid composition
Temperature
Give the 3 types of membrane-associated proteins.
Integral membrane proteins
Attached proteins
Peripheral, membrane-associated proteins
Give 3 functions of membrane proteins.
Transporters
Linkers
Receptors
Enzymes
What is the function of transporter membrane proteins?
To move nutrients, metabolites or ions across membranes
What is the function of membrane linker proteins?
To join membranes to intra- or extracellular macromolecules
What is the function of receptor proteins?
To transduce signals from the environment
To transport ligands
What is the glycocalix?
A cell coat which protects against chemical, physical and biological damage
Name 2 examples of glycoproteins.
N-glycans
O-glycans
Proteoglycans
Name 2 ways in which glycans affect health and disease.
Modulate inflammatory responses enabling viral immune escape
Promote cancer cell metastasis
Give 3 functions of the glycocalix.
Protection
Adhesion
Recognition
Storage
What is FRAP?
Fluorescent Recovery after Photobleaching
How do proteins move within the membrane?
Diffusion along membrane plane