CMB1004/L28 Adrenal Glands Flashcards

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1
Q

Describe the location of the adrenal glands anatomically.

A

Sit on top of each kidney

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2
Q

What is the combined weight of adrenal glands in an adult?

A

8-10g

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3
Q

What kind of hormones are produced in the cortex of the adrenal glands?

A

Steroid hormones

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4
Q

What kind of hormones are produced in the medulla of the adrenal glands?

A

Amino acid hormones

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5
Q

What kind of tissue is the adrenal cortex derived from?

A

Mesodermal tissue surrounding kidneys

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6
Q

What kind of tissue is the adrenal medulla derived from?

A

Neural crest tissues

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7
Q

What is the neurotransmitter of the sympathetic nervous system?

A

Norepinephrine

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8
Q

Give the 3 ‘zones’ of the adrenal cortex, from inside-outwards.

A

Zona reticularis
Zona fasiculata
Zona glomerulosa

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9
Q

What hormone is produced by the zona glomerulosa (outer layer)?

A

Aldosterone

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10
Q

What hormone acts on receptors in zona glomerulosa?

A

Angiotensin II

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11
Q

What hormones are produced by the zona fasiculata (middle layer)?

A

Cortisol and androgens

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12
Q

What hormones are produced by the zona reticularis (inner layer)?

A

Cortisol and androgens

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13
Q

What hormones are produced by the adrenal medulla?

A

Mostly epinephrine
Some pre-methylated noradrenaline

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14
Q

What enzyme is lacked in the zona glomerulosa?

A

17 alpha-hydroxylase

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15
Q

What kind of molecule is aldosterone?

A

Mineralocorticoid

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16
Q

What is the half-life of aldosterone?

A

15-20 minutes

17
Q

What is the function of aldosterone?

A

On kidney, colon and salivary glands
Maintains normal Na+ concentration and extracellular fluid volume

18
Q

Describe the action of aldosterone. (3)

A

Binds to mineralocorticoid receptors within principal cells
Upregulates ENaC
Upregulates and activates Na+/K+ ATPase

19
Q

What is the Na+ reabsorption with and without aldosterone?

A

Without: 98%
With: >99.6%

20
Q

What hormone is cleaved by renin to form angiotensin I?

A

Angiotensinogen

21
Q

What molecule forms angiotensin II from angiotensin I?

A

ACE

22
Q

What organs does angiotensin II work on? (3)

A

Vasculature
Hypothalmaus
Adrenal glands (cortex)

23
Q

What enzyme is lacked in the zona fasiculata and zona reticularis?

A

CYP11B2 gene
P450aldo

24
Q

What kind of molecule is cortisol (hydrocortisone)?

A

Glucocorticoid

25
Q

What is the half-life of cortisol?

A

60-90 minutes

26
Q

Give 2 effects of cortisol on glucose metabolism.

A

Stimulates hepatic gluconeogenesis
Inhibits glucose uptake in muscle and adipose tissue

27
Q

What effect does cortisol have on muscle catabolism?

A

Stimulation of muscle catabolism

28
Q

Give 3 effects of cortisol, NOT including glucose metabolism.

A

Inhibits bone formation
Leads to loss of collagen and connective tissue
Increases vascular sensitivity to epinephrine and norepinephrine
Can modulate behaviour and cognitive function
Inhibits gonadal release of testosterone, oestrogen and progestins

29
Q

How do glucocorticoids produce anti-inflammatory and immunosuppression effects? (2)

A

Inhibits cytokine production and T cell proliferation
Inhibits prostaglandin and leukotriene production

30
Q

Which part of the adrenal glands will respond to adrenocorticotropic hormone?

A

Zona fasiculata
Zona reticularis

31
Q

What is the affinity of cortisol for mineralocorticoid receptors in relation to aldosterone?

A

100x more

32
Q

What enzyme prevents the mineralocorticoid effects of cortisol being greater?

A

11 beta-hydroxysteroid dehydrogenase in aldosterone responsive cells