Clinical Aspects of Pituitary Disease Flashcards
what are the clinical features of acromegaly
spade like hands
wide feet
coarse facial features
thick lips
what are complications of acromegaly
headache
chiasmal compression
diabetes
what are the investigations for acromeagly
- test to see if GH can be supressed
- is there elevated IGF-1
- is there a pituitary tumour
what is cushings syndrome
excess corticosteroids
what are signs and symptoms of cushings syndrome
skin atrophy
spontaneous purpura
proximal myopathy
osteoporosis
what are ACTH dependent causes of cushings syndrome
pituitary tumour (Cushings Disease) Ectopic ACTH secretion (lung carcinoid)
what are ACTH independent causes of cushings syndrome
adrenal tumour
corticosteroid therapy
what are the clinical signs of hyperprolactinaemia in women
glactorrhoea
menstural irregularity
infertility
what are the clinical signs of hyperprolactinaemia in men
impotence
headache
visual field abnormalities
what type of drugs can cause hyperprolactinaemia
dopamine depleting
dopamine antagonists
what are clinical features of hypopituitarism
tiredness depression weight gain reduced libido menstrual problems impotence
what is diabetes insipidus
rare condition where you produce large amount of urine and often feel thirsty, can be due to hypothalamus or pituitary gland damage
what is the cause of diabetes insipidus
lack of vasopressin (so kidneys can concentrate urine)
what test can diagnose diabetes insipidus
water deprivation test
what is the treatment of hyperprolactinoma
dopamine agonists
