Chemistry of Life 1 - MT1 - Part 3 Flashcards
What are most lipid molecules made up of?
Hydrocarbons
- C and H atoms
What do lipids not like?
Water
- not soluble in water
What are 4 types of lipids?
- Fatty acids
- Triglycerides
- Phospholipids
- Sterols
What are fatty acids?
Components of larger lipid molecules
What do fatty acids contain/require?
- Contains O2
- Requires a negative charge
Are fatty acids branched on unbranched?
Unbranched
What are triglycerides used for? (2)
- Energy source
2. Storgage
What are triglycerides build from?
Fatty acids
- 3 fatty acid chains
Unsaturated triglycerides with example
Contains kinks in their tails so they do not pack well together nicely resulting in a more liquid like substance at room temp
- eg) Oils
Saturated triglycerides
Does not contain kinks so they pack well together nicely resulting in a more solid like from at room temp
What happens if you put random phospholipids in water?
They will form spontaneously so that the tails are in the middle (away from the water) and the heads are on the outside (facing water)
What 2 things are sterols good for?
- Chemical signalling
2. Membrane stabilization
What are 3 examples of sterols?
- Cholesterol
- Estradiol
- Testosterone
Hormone
A regulatory substance produced in an organism and transported in tissue fluids
What makes up proteins?
Polymers of amino acids
What are 5 functions of proteins?
- Catalysis of biochemical reactions
- Structure and movement
- Transport of materials across membrane
- Transmission of signals
- Defense
What do catalysis do?
They are enzymes that speed up the process of breaking chemical bonds of a large molecule
What are the 3 steps for a catalysis?
- Substance binds to the active site of a specific molecule
- The active site of the enzyme changes shape
- Enzyme releases the resulting products and the enzyme is ready to be used again
- it gets regenerated to its original form
What are 2 examples of structure and movement?
- Cytoskeleton
- microtubules interacting with actin - Extracellular matrix
What do proteins provide for movement?
Channels to transport specific substances across the membrane
What is an example of transmission of signal?
Insulin
Insulin
It is a signal from the pancreas that instructs cells to take up more glucose from the bloodstream
What is an example of a defense molecule?
Antibodies
Antibody
Is a blood protein produced in response to and counteracting a specific antigen
- help to recognize foreign substances in the body
Hemoglobin (8)
- Model molecule
- Readily available
- Found in RBC
- 2 alpha 2 beta subunits
- Transports O2
- Can change its shape (not static)
- Binds O2 to heme group
- Binding of one O2 changes the interaction around the whole molecule (not just that region)
What make up nucleic acids?
Polymers of nucleotides
DNA
Made up of 2 stands, twisted into a helix form
What are the 4 subunits of DNA?
T = Thymine A = Adenine C = Cytosine G = Guanine
What varies in DNA and what stays the same?
- The nucleotides (subunits) vary
- The backbone stays the same
- -> P group attached to a sugar
RNA
Single strand of nucleotides
What 3 things are DNA/RNA critical for?
- Storage
- Transmission
- Execution of genetic instructions
What are 3 functions of nucleic acids?
- Information storage and retrieval
- Energy currency and transfer (ATP)
- Electron currency and transfer (NAD+/NADH)
Energy from catabolism
Exergonic –> energy releasing processes
Energy for cellular work
Endergonic –> energy consuming processes
What do NAD/NADH do?
They are electron carriers
What are 3 structures/properties of nucleic acids?
- DNA is a double stranded helix
- Associated by complementary base pairing
- DNA double helix can unwind
What is held together the same way as DNA?
Water
What is the most significant feature of DNA structure?
The association though complementary base pairing
What are the complementary base pairs held together by?
Weak H bonds
What shape is a low conformation (low energy) form of the molecule?
Helical shape of DNA
What does G bind to?
C
What does A bind to?
T
What happens to DNA strand when heat is added?
It gets denatured and unwinds
Glycoproteins
Exterior surface of the cell
Glycolipids
Lipids with a carbohydrate attached by a glycosidic bond
What do glycolipids do?
Maintains stability of the cell
What are 2 examples of non-covalent associations of biomolecules?
- Chromatin
2. Ribosomes
Chromatin
DNA and proteins
- chromosomes are made up of chromatids
Co-factors
A substance who’s presence is essential for activity of enzymes
Vitamins
Essential for normal growth and nutrition
Mineral ions
Small ions needed for processes in our body
What are 4 examples of mineral ions?
- Na
- K
- Cl
- Fe