Chapter 7 - Nervous System Flashcards
the nervous sytem enables organisms to
receive and respond to stimuli from their external and internal environments
neurons
functional units of nervous system
neuron converts stimuli into
electrochemical signals
electrochemical signals are
conducted through nervous system
the nervous system responds ____ to stimuli than the endocrine system
more rapidly
the neuron consists of
elongated cell consisting of several dendirtes, a body, a single axon
dendrites
form & fxn
cytoplasmic extensions that receive information and transmit it towards the cell body
cell body (soma)
contains nucleus and controls metabolic activity of the neuron
axon
long cellular process that transmits impulses away from teh cell body
most mammalian neuron body and axon are
sheathed by insulating substance - myelin
myelin
sheates body and axon of neuron
allows axons to conduct impulses faster
myelin produced by
glial cells
oligodendrocytes
produce myelin in central nervous system
schwann cells
produce myelin in peripheral nervous system
nodes or Ranvier
gaps between segments of myelin
axons end as swellings known as
synaptic terminals
neurotransmitters released from ____ into _____
synaptic terminals;
synapse (synaptic cleft)
synapse (synaptic cleft)
gap between axon terminals of one cell and dendrites of next cell
axons travelling from spine to tip of foot may be
very long
neurons are specialized to
receive signals from sensory receptors or other neurons in body and transfer information along length of axon
action potentials are
impulses that travel the length of the axon and invade the nerve terminal
action potentails cause
release of neurotransmitters into the synapse
resting potential
potential difference between extracellular space and intracellular space when neuron is at rest
even at rest, a neuron is
polarized
potential difference is the result of
unequal distribution of ions between inside and outside of the cell
typical resting membrane potential is
-70 millivolts
typical resting membrane potential of -70 mv means that the inside of the neuron is
more negative than the outside
the potential difference is due to
selective ionic permeability of neuronal cell membrane
the potential difference is maintained by
active transport by Na+/K+ pump
concentration of K+ is higher _____
the concentration of Na+ is higher ____
inside; outside
in addition to K+/Na+ difference; negatively charged proteins are
trapped inside cell
the resting potential is created because the neuron is selectively permeable to
K+
selective permeability of neuron to K+ means that
K+ diffuses down its concentration gradient, leaving net negative charge inside
neurons are impermeable to
Na+
because neurons are impermeable to Na+
cell remains polarized
ionic gradients are restored by
Na+/K+ pumps
the Na+/K+ pump operates using ____ for energy
ATP
the Na+/K+ pump transports _____ out for every ____ transported into the cell
3 Na+
2 K+
nerve cell body receives both ____ and _____ impulses from other cells
excitatory and inhibitory impulses
action potential generated when
cell becomes sufficiently excited
or
depolarized (less negative)
the minimum threshold membrane potential is
-50 mV
the minimum threshold membrane potential is the level at which
action potential is initiated
Na+ wants to go ____ the cell because _____
into;
it is more negative inside hte cell (electrical gradient) and there is less Na+ inside (chemical gradient)
in response to changes in voltage,
ion channels located in nerve cell membrane open
voltage-gated ion channels
ion channels located in nerve cell membrane that open in response to changes in voltage are called
action potential begins when
voltage-gated Na+ channel open in response to depolarization
voltage-gated Na+ channels open in response to
depolarization
the opening of the voltage-gated Na+ channels allows Na+ to
rush down electrochemical gradient into the cell
depolarization leads to opening the voltage-gated Na+ channels, allowing Na+ to rush down its electrochemical gradient into the cell
this causes
rapid further depolarization of that segment of the cell
after the cascade of depolarization, the voltage-gated Na_ channels close and then
the voltage-gated K+ channels open and K+ rushes out down electrochemical gradient
voltage-gated K+ channels opening and allowing K+ ions to rush down the electrochemical gradient allows for
the cell to return to a mor enegative potential
repolarization
the cell returning to a more negative potential after the voltage-gated K+ channels open to allow K+ ions to rush down the electrochemical gradient to balance the depolarization of the Na+ ions
hyperpolarization
neuron may shoot past resting potential and become even more negative inside than normal
refractory period
immediately following action potential, may be very difficult or impossible to initiate another action potential
all-or-none response
action potential all-or none response
when threshold membrane potential is reached, action potential with consistent size and duration is produced
nerve fires maximally or not at all
stimulus intensity is coded by
frequency of action potentials
axons can theoretically propagate action potentials bidirectionally, however, information transfer occurs only
in one direction:
dendrite —> synaptic terminal
backward information transfer through the axon is impossible because
synapses operate only in one direction
and
refractory periods make backward travel of action potentials impossible
speeds of action potentials
different axons can propagate action potentials at different speeds
speed of action potential depends on
the greater the diameter
and
the more heavily it is myelinated
the faster the impulses
myelin increases conduction of velocity down the axon by
insulating segments of hte axon
membrane permeable to ions only at nodes of Ranvier
action potential “jumps” from node to node
synapse
gap between axon terminal of one neuron and dendrites of another neuron
presynaptic neuron
neuron before synapse
postsynaptic neuron
neuron after synapse
neurons may communicate with
neurons
muscles or glands
effector cell
The muscle, gland or organ cell capable of responding to a stimulus at the terminal end of an efferent neuron or motor neuron.
neurotransmitters
chemical messengers stored in membrane-bound vesicles at the nerve terminal
nerve terminal contains thousands of membrane-bound vesciles full of
neurotransmitters
(chemical messengers)
when the action potential arrives at the nerve terminal and depolarizes it
the synaptic vesicles fuse with the presynaptic membrane and release neurotransmitters into the synapse
once the synaptic vesicles fuse with presynaptic membrane and release neurotransmitters into the synapse,
the neurotransmitter…
diffuses across the synapse and acts on receptor proteins embedded in the postsynaptic membrane
neurotransmitters diffuse across the synapse and act on
receptor proteins on the post-synaptic membrane
the neurotransmitter can lead to ____ on the post-synaptic cell and consequent _____
depolarization;
firing an action potential
how is neurotransmitter removed from synapse?
(3)
- taken back up into nerve terminal via uptake carrier (protein)
- degraded by enzymes located in the synapse
- diffuse out of synapse
neurotransmitmter may be taken back into the nerve terminal from synapse via
a protein: uptake carrier
enzymes that may degrade neurotransmitters in the synapse
acetylcholinesterase inactivates neurotransmitter acetylcholine
curare
(drug)
blocks post-synaptic acetylcholine receptors so that acetylcholine is unable to interact with receptor
leads to paralysis by blocking nerve impluses to muscles
botulism toxin
prevents realease of acetylcholine from pre-synaptic membrane
results in paralysis
anti-cholinesterases
used as nerve gases and in insecticide parathion
inhibit activity in acetylcholinesterase enzyme
acetylcholine is not degraded in the synapse and continues to affect post-synaptic membrane
no coordinated muscular contractions can take place