Chapter 65 - Non-regenerative anemia

Question 1

Erythropoeitin is primarily stimulated by what?

Answer 1

Hypoxia

Question 2

How long do erythrocytes live in the dog? In the cat?

Answer 2

104 days in dog, 73 days in cat

Question 3

In dogs with non-regenerative anemia, physiological compensation is acheived by what?

Answer 3

increasing cardiac output via nitric oxide mediated vasodilation, as well as rheological changing promoting lower systemic vascular resistance

Question 4

What changes are expected in the following CBC criteria for a non-regenerative anemia? Reticulocyte count, anisocytosis, polychromasia, MCV, MCHC, RDW

Answer 4

retics - low normal, anisocytosis - absent, polychromasia - absent, MCV normal, MCHC normal, RDW normal

Question 5

Where are the most common sites for bone marrow aspiration?

Answer 5

Proximal humerus, iliac crest, trochanteric fossa of femur

Question 6

How does hepcidin contrinbute to anemia of chronic disease?

Answer 6

It produces a state of relative iron deficiency, blunting erythropoesis