Chapter 111 - Hypoglycemia

Question 1

Mechanism of action of glucagon

Answer 1

• Stimulates glycogenolysis in the liver via cyclic AMP production and subsequent phosphorylation of glycogen phosphorylase

Question 2

Predominant transporter in the brain vasculature?

Answer 2

GLUT 1

Question 3

Initial and severe clinical signs : type and glucose value

Answer 3

restlessness, muscle tremors or Nervousness
(plasma glucose level < 68 mg/dL)
Lethargy, ataxia, seizures, and coma : plasma glucose< 18 mg/dL

Question 4

Causes for amended insulin:glucose

ratio (AIGR) of > 30 ?

Answer 4

• insulinoma
• sepsis
• non-pancreatic neoplasia