chapter 5 part 1 Flashcards
syntenic genes
genes located on the same chromosome
linked genes
genes close enough on the same chromosome so they assort together more often than independently
on more closely linked genes, is there more or less crossing over
less
what units are used to express the distance between genes
map units
max value for recombination frequency
50%
why is genetic linkage quantified
to map the positions of the genes on chromosomes
homologs that reshuffle produce
recombinant chromosomes
homologs that don’t reshuffle produce
parental/nonrecombinant chromosomes
genetic linkage mapping
plots positions of genes on chromosomes
complete genetic linkage
observed when no crossing over occurs between linked genes
is incomplete or complete linkage more common?
incomplete
are parental and recombinant types equal?
no
does crossing over occur more between genes that are farther apart or closer together
farther part
genetic linkage is a _________ relationship among genes located near one another on a chromosome
physical
what is recombination between genes accompanied by
physical exchange between the homologs - chromosome breakage and rejoining in plants and animals
who showed that crossover is accompanied with breakage and rejoining
Creighton and McClintock
who first demonstrated that genes are on chromosomes
Morgan
who was Morgan’s student
Alfred Sturtevant
what did Alfred Sturtevant use the results of several experiments to create
genetic map for 5 X-linked genes in Drosophila
what is a map unit also called
centiMorgan (cM)
recombination hotspots
where recombination and crossing over occurs at much higher rate
hotspots and cold spots may lead to what
placement of genes farther apart or closer together on recombination map than on physical map
what may hotspots and cold spots be due to
feasibility of DNA in those regions to initiate crossing over
recent studies indicate that recombination occurs primarily where?
at specific hotspots
ex. of organism with complete linkage
Drosophila
what test is used to detect genetic linkage?
two-point test-cross analysis